α,β-Methylene-ATP dilithium

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α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand. α,β-Methylene ATP dilithium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7.

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α,β-Methylene-ATP dilithium Chemical Structure

CAS No. : 104809-20-3

Size	Stock	Quantity
1 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of α,β-Methylene-ATP dilithium:

α,β-Methylene-ATP trisodium Get quote
α,β-Methylene-ATP Get quote

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

Biological Activity
Purity & Documentation
References
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Description

α,β-Methylene ATP dilithium, a phosphonic analog of ATP, is a P2X3 and P2X7 receptor ligand^[1]. α,β-Methylene ATP dilithium is a highly selective agonist for P2X1 and P2X3, with practically no activity at P2X2,4-7^[2].

IC₅₀ & Target

p2x1 Receptor

P2X3 Receptor

P2X7 Receptor

Molecular Weight

519.09

Formula

C₁₁H₁₈Li₂N₅O₁₂P₃

CAS No.

104809-20-3

SMILES

OP(OP(CP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)(O)=O)(O)=O.[Li].[Li]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Arribas-Blázquez M, et al. Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. Int J Mol Sci. 2019 Jan 3;20(1). [Content Brief]

[2]. Claudio Coddou, et al. Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev. 2011 Sep;63(3):641-83 [Content Brief]