β-Aminopropionitrile hydrochloride (Synonyms: BAPN hydrochloride)

Cat. No.: HY-Y1750A: FAQs
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β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes.

For research use only. We do not sell to patients.

β-Aminopropionitrile hydrochloride Chemical Structure

CAS No. : 646-03-7

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Other Forms of β-Aminopropionitrile hydrochloride:

3-Aminopropionitrile fumarate (2:1) Get quote
β-Aminopropionitrile Get quote

2 Publications Citing Use of MCE β-Aminopropionitrile hydrochloride

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Biological Activity
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References
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Description

IC₅₀ & Target

Lysyl Oxidase

In Vitro

β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance^[1].
β-Aminopropionitrile (500 μM; 72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	3T3-L1 adipocytes
Concentration:	200 μM with 1.15 nM and 2.87 nM TNFα
Incubation Time:	72 h
Result:	TNFα reduced expression of GLUT4 and adiponectin, and increased SOCS3 protein levels in these cells. And these effects were prevented.

Cell Invasion Assay^[2]

Cell Line:	HeLa and SiHa cells
Concentration:	500 μM
Incubation Time:	72 h
Result:	Significantly reduced hypoxia-elicited cell invasion in both cell models.

Cell Migration Assay ^[2]

Cell Line:	HeLa and SiHa cells
Concentration:	500 μM
Incubation Time:	72 h
Result:	Decreased hypoxia-induced migration from 180 and 240% to 60 and 70% in HeLa and SiHa cells, respectively.

Western Blot Analysis^[2]

Cell Line:	HeLa and SiHa cells
Concentration:	500 μM
Incubation Time:	72 h
Result:	Effectively prevented hypoxia-induced downregulation of E-cadherin and strongly inhibited hypoxia-induced upregulation of α-SMA and vimentin.

In Vivo

β-Aminopropionitrile (BAPN) (100 mg/kg/day; p.o.; 6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats^[1].
β-Aminopropionitrile monofumarate (1 g/kg/day; p.o.; 4 weeks) induces thoracic aortic dissection in C57BL/6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats of 150 g, high-fat diet (HFD) model^[1]
Dosage:	100 mg/kg/day
Administration:	In the drinking water, 6 weeks
Result:	Significantly prevented the rise in body weight in HFD rats, but not in animals that were fed a standard diet. Reduced the increase in the weight of white adipose tissue (both epididymal and lumbar) in obese animals and attenuated their enhanced adiposity. Improved fasted glucose and insulin levels and consequently reduced HOMA index in the HFD group. Improved insulin signalling in adipose tissue from obese animals.

Animal Model:	C57BL/6 mice^[3]
Dosage:	1 g/kg/day
Administration:	In the drinking water, 4 weeks
Result:	Induce thoracic aortic dissection (TAD) in all mice with 24 h of Ang II infusion. Caused 87% of C57BL/6 mice to develop TAD without Ang II.

Molecular Weight

106.55

Formula

C₃H₇ClN₂

CAS No.

646-03-7

SMILES

NCCC#N.Cl

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51. [Content Brief]

[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8. [Content Brief]

[3]. Ren W, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016 Jun 22;6:28149. [Content Brief]

β-Aminopropionitrile hydrochloride Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Aminopropionitrile646-03-7BAPNMonoamine OxidaseEndogenous MetaboliteMAOthoracic aortic dissectionGLUT4insulincervical carcinoma cellsHeLaSiHaobesitylysyl oxidaseInhibitorinhibitorinhibit

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