β-Benzamide adenine dinucleotide 

β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide nucleoside and a potent inhibitor of inosine 5 '-monophosphate dehydrogenase (IMPDH). β-Benzamide adenine dinucleotide is a potent, competitive inhibitor of human NAD kinase (K_i = 90 µM)^[1][2].

662.44

C₂₂H₂₈N₆O₁₄P₂

156724-91-3

O[C@@H]1[C@H](O)[C@@H](COP(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](C3=CC=CC(C(N)=O)=C3)O2)(O)=O)(O)=O)O[C@H]1N(C=N4)C5=C4C(N)=NC=N5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lesiak K, et al. Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity. J Med Chem. 1997 Aug 1;40(16):2533-8.  [Content Brief]

  [2]. Bonnac L, et al. Probing binding requirements of NAD kinase with modified substrate (NAD) analogues. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1512-5.  [Content Brief]