2. MAPK/ERK Pathway Stem Cell/Wnt Metabolic Enzyme/Protease
  3. ERK MMP
  4. β-Neo-Endorphin

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9.

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β-Neo-Endorphin Chemical Structure

β-Neo-Endorphin Chemical Structure

CAS No. : 77739-21-0

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Based on 1 publication(s) in Google Scholar

Other Forms of β-Neo-Endorphin:

β-Neo-Endorphin Related Antibodies

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Description

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, MMP-2 and MMP-9[1][2].

IC50 & Target

ERK1

 

ERK2

 

MMP-2

 

MMP-9

 

In Vitro

β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes[2].
β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes[2].
β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9[2].
β-Neo-Endorphin (12 h) stimulates migration in the fibroblast[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Neo-Endorphin Related Antibodies

Cell Viability Assay[2]

Cell Line: Human keratinocytes (HaCaT)
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 20 h
Result: Significantly increased the wound closure. Had no observable effect on cell viability.

Western Blot Analysis[2]

Cell Line: Human keratinocytes (HaCaT)
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 12 h
Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression.
Molecular Weight

1100.27

Formula

C54H77N13O12
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YGGFLRKYP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (90.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9089 mL 4.5443 mL 9.0887 mL
5 mM 0.1818 mL 0.9089 mL 1.8177 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9089 mL 4.5443 mL 9.0887 mL 22.7217 mL
5 mM 0.1818 mL 0.9089 mL 1.8177 mL 4.5443 mL
10 mM 0.0909 mL 0.4544 mL 0.9089 mL 2.2722 mL
15 mM 0.0606 mL 0.3030 mL 0.6059 mL 1.5148 mL
20 mM 0.0454 mL 0.2272 mL 0.4544 mL 1.1361 mL
25 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9089 mL
30 mM 0.0303 mL 0.1515 mL 0.3030 mL 0.7574 mL
40 mM 0.0227 mL 0.1136 mL 0.2272 mL 0.5680 mL
50 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4544 mL
60 mM 0.0151 mL 0.0757 mL 0.1515 mL 0.3787 mL
80 mM 0.0114 mL 0.0568 mL 0.1136 mL 0.2840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Neo-Endorphin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Neo-Endorphin77739-21-0ERKMMPExtracellular signal regulated kinasesMatrix metalloproteinasesmouse embryonic fibroblastsMEF cellsHuman keratinocytesHaCaTopioidpeptidewound healingInhibitorinhibitorinhibit

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