2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. β-Pompilidotoxin

β-Pompilidotoxin  (Synonyms: β-PMTX)

Cat. No.: HY-P1084 Purity: 97.12%
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β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Pompilidotoxin Chemical Structure

β-Pompilidotoxin Chemical Structure

CAS No. : 216064-36-7

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5 mg USD 120 In-stock
10 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of β-Pompilidotoxin:

β-Pompilidotoxin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Pompilidotoxin (β-PMTX), a wasp venom, can slow sodium channel inactivation and increases steady-state sodium current in cells[1].

In Vitro

β-Pompilidotoxin (β-PMTX) increases resurgent current in wild-type neurons and induced resurgent current in med neurons. β-Pompilidotoxin (10 μM) modestly but significantly increased the decay time constant (τdecay) of currents evoked by a step from -90 to 0 mV from 0.52 to 0.73 msec in wild-type Purkinje cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Pompilidotoxin Related Antibodies
Molecular Weight

1557.88

Formula

C71H124N22O17
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu-NH2
Sequence Shortening

RIKIGLFDQLSRL-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (64.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6419 mL 3.2095 mL 6.4190 mL
5 mM 0.1284 mL 0.6419 mL 1.2838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6419 mL 3.2095 mL 6.4190 mL 16.0474 mL
5 mM 0.1284 mL 0.6419 mL 1.2838 mL 3.2095 mL
10 mM 0.0642 mL 0.3209 mL 0.6419 mL 1.6047 mL
15 mM 0.0428 mL 0.2140 mL 0.4279 mL 1.0698 mL
20 mM 0.0321 mL 0.1605 mL 0.3209 mL 0.8024 mL
25 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6419 mL
30 mM 0.0214 mL 0.1070 mL 0.2140 mL 0.5349 mL
40 mM 0.0160 mL 0.0802 mL 0.1605 mL 0.4012 mL
50 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.3209 mL
60 mM 0.0107 mL 0.0535 mL 0.1070 mL 0.2675 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Pompilidotoxin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Pompilidotoxin216064-36-7β-PMTXSodium ChannelNa channelsNa+ channelsInhibitorinhibitorinhibit

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