γ-Fibrinogen 377-395 TFA 

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation^[1].

γ-Fibrinogen377-395 TFA (200 μM) blocks fibrin binding to Mac-1 that inhibits and adhesion of Mac-1–overexpressing cells to immobilized fibrinogen. γ-Fibrinogen377-395 TFA inhibits microglia activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Fibrinogen377-395 TFA (30 μg/mouse; administered intranasally; once daily for 40 days) increases motor functions of mouse without affecting the peripheral immune response. γ-Fibrinogen377-395 TFA does not affect the coagulation properties of fibrinogen^[1].
Immunized with γ377-395 peptide before EAE induction, γ377-395 peptide-vaccinated mice has an increases in motor strength and coordination compared with control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2343.68

C₁₀₂H₁₆₆F₃N₂₅O₃₀S₂

Solid

White to off-white

Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly

YSMKETTMKIIPFNRLSIG

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Adams RA, et al. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007 Mar 19;204(3):571-82.  [Content Brief]