2. Peptides
  3. Peptide and Derivatives
  4. Peptide Epitopes
  5. γ-Fibrinogen 377-395 TFA

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.

For research use only. We do not sell to patients.

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γ-Fibrinogen 377-395 TFA Chemical Structure

γ-Fibrinogen 377-395 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of γ-Fibrinogen 377-395 TFA:

γ-Fibrinogen 377-395 TFA Related Antibodies

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Description

γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation[1].

In Vitro

γ-Fibrinogen377-395 TFA (200 μM) blocks fibrin binding to Mac-1 that inhibits and adhesion of Mac-1-overexpressing cells to immobilized fibrinogen. γ-Fibrinogen377-395 TFA inhibits microglia activation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Fibrinogen 377-395 TFA Related Antibodies
In Vivo

γ-Fibrinogen377-395 TFA (30 μg/mouse; administered intranasally; once daily for 40 days) increases motor functions of mouse without affecting the peripheral immune response. γ-Fibrinogen377-395 TFA does not affect the coagulation properties of fibrinogen[1].
Immunized with γ377-395 peptide before EAE induction, γ377-395 peptide-vaccinated mice has an increases in motor strength and coordination compared with control[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PLP139-151-immunized mice with experimental autoimmune encephalomyelitis (EAE)[1]
Dosage: 30 μg/mouse
Administration: Administered intranasally; daily after the first paralytic episode in remitting relapsing EAE
Result: Reduced the progression and severity of EAE by specifically targeting microglia/macrophage activation in the CNS parenchyma without adverse hemorrhagic effects.
Molecular Weight

2343.68

Formula

C102H166F3N25O30S2
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly
Sequence Shortening

YSMKETTMKIIPFNRLSIG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (21.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4267 mL 2.1334 mL 4.2668 mL
5 mM 0.0853 mL 0.4267 mL 0.8534 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4267 mL 2.1334 mL 4.2668 mL 10.6670 mL
5 mM 0.0853 mL 0.4267 mL 0.8534 mL 2.1334 mL
10 mM 0.0427 mL 0.2133 mL 0.4267 mL 1.0667 mL
15 mM 0.0284 mL 0.1422 mL 0.2845 mL 0.7111 mL
20 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.5333 mL
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γ-Fibrinogen 377-395 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Fibrinogen 377-395OthersInhibitorinhibitorinhibit

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