2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. γ-Glu-Val-Gly

γ-Glu-Val-Gly is a cleavable ADC linker.

For research use only. We do not sell to patients.

γ-Glu-Val-Gly Chemical Structure

γ-Glu-Val-Gly Chemical Structure

CAS No. : 38837-70-6

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γ-Glu-Val-Gly Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

γ-Glu-Val-Gly is a cleavable ADC linker.

IC50 & Target

Cleavable Linker
Molecular Weight

303.31

Formula

C12H21N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CCC(N[C@@H](C(C)C)C(NCC(O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (412.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2970 mL 16.4848 mL 32.9696 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2970 mL 16.4848 mL 32.9696 mL 82.4239 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL 16.4848 mL
10 mM 0.3297 mL 1.6485 mL 3.2970 mL 8.2424 mL
15 mM 0.2198 mL 1.0990 mL 2.1980 mL 5.4949 mL
20 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1212 mL
25 mM 0.1319 mL 0.6594 mL 1.3188 mL 3.2970 mL
30 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7475 mL
40 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
50 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6485 mL
60 mM 0.0549 mL 0.2747 mL 0.5495 mL 1.3737 mL
80 mM 0.0412 mL 0.2061 mL 0.4121 mL 1.0303 mL
100 mM 0.0330 mL 0.1648 mL 0.3297 mL 0.8242 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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γ-Glu-Val-Gly Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Glu-Val-Gly38837-70-6ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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