2. Immunology/Inflammation
  3. Interleukin Related
  4. 1,11b-Dihydro-11b-hydroxymedicarpin

1,11b-Dihydro-11b-hydroxymedicarpin  (Synonyms: 11b-Hydroxy-11b,1-dihydromedicarpin)

Cat. No.: HY-N0976
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1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice.

For research use only. We do not sell to patients.

1,11b-Dihydro-11b-hydroxymedicarpin Chemical Structure

1,11b-Dihydro-11b-hydroxymedicarpin Chemical Structure

CAS No. : 210537-04-5

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Based on 1 publication(s) in Google Scholar

1,11b-Dihydro-11b-hydroxymedicarpin Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

Cellular Effect
Cell Line Type Value Description References
U-937 IC50
> 100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]
Molecular Weight

288.30

Formula

C16H16O5
CAS No.
SMILES

O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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1,11b-Dihydro-11b-hydroxymedicarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,11b-Dihydro-11b-hydroxymedicarpin210537-04-511b-Hydroxy-11b,1-dihydromedicarpinInterleukin RelatedILpterocarpaninflammatoryInhibitorinhibitorinhibit

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