1,2'-O-Dimethylguanosine

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1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).

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1,2'-O-Dimethylguanosine Chemical Structure

CAS No. : 73667-71-7

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Description	1,2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)^[1].
Molecular Weight	311.29
Formula	C₁₂H₁₇N₅O₅
CAS No.	73667-71-7
SMILES	OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N(C=N2)C3=C2C(N(C)C(N)=N3)=O)O1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. [Content Brief]