2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Immunology/Inflammation
  3. Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
  4. 1,3,5-Trihydroxy-4-prenylxanthone

1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.

For research use only. We do not sell to patients.

1,3,5-Trihydroxy-4-prenylxanthone Chemical Structure

1,3,5-Trihydroxy-4-prenylxanthone Chemical Structure

CAS No. : 53377-61-0

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1,3,5-Trihydroxy-4-prenylxanthone Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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nNOS iNOS eNOS

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Description

1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL[1]. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM[3]. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities[2].

IC50 & Target[1][2][3]

PDE5

3 μM (IC50)

iNOS

 

Na+/H+ Exchanger

 

In Vitro

1,3,5-Trihydroxy-4-prenylxanthone (10-30 μM; 18 hours) shows a suppression of LPS-induced iNOS expression through abolishing IKK phosphorylation, IκB degradation and NF-κB nuclear translocation. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced iNOS expression by interference with the posttranslational modification of IRAK-1 resulted in blocking TAK1-mediated activation of IKK and MAPKs signal transduction to down-regulate NF-κB and AP-1 activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,3,5-Trihydroxy-4-prenylxanthone Related Antibodies

Western Blot Analysis[2]

Cell Line: RAW264.7 macrophages
Concentration: 10 μM, 20 μM and 30 μM
Incubation Time: 18 hours
Result: Showed suppression of LPS-induced iNOS expression. Suppressed the nuclear level of c-Fos and c-Jun (major components of activator protein-1, AP-1) and the phosphorylated level of upstream signal molecules, such as JNK and ERK.
Molecular Weight

312.32

Formula

C18H16O5
CAS No.
SMILES

C/C(C)=C\CC1=C2C(C(C3=C(C(O)=CC=C3)O2)=O)=C(O)C=C1O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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1,3,5-Trihydroxy-4-prenylxanthone Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

1,3,5-Trihydroxy-4-prenylxanthone53377-61-0Na+/H+ Exchanger (NHE)Phosphodiesterase (PDE)NO SynthaseSodium/hydrogen ExchangerSodium-hydrogen ExchangerNitric oxide synthasesNOSNF-κBAP-1iNOSIκBTAK1IKKanti-inflammatory activitiesNa+/H+ exchange systemPDE5Inhibitorinhibitorinhibit

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