2. PROTAC
  3. PROTAC Linkers
  4. 1,3-Dibromo-5,5-dimethylhydantoin

1,3-Dibromo-5,5-dimethylhydantoin 

Cat. No.: HY-Y0786 Purity: ≥98.0%
SDS COA Handling Instructions

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1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

1,3-Dibromo-5,5-dimethylhydantoin Chemical Structure

1,3-Dibromo-5,5-dimethylhydantoin Chemical Structure

CAS No. : 77-48-5

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Based on 1 publication(s) in Google Scholar

1,3-Dibromo-5,5-dimethylhydantoin Related Antibodies

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Description

1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1,3-Dibromo-5,5-dimethylhydantoin Related Antibodies
Molecular Weight

285.92

Formula

C5H6Br2N2O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1N(Br)C(C(C)(C)N1Br)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (349.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4975 mL 17.4874 mL 34.9748 mL
5 mM 0.6995 mL 3.4975 mL 6.9950 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (941 KB)

COA (255 KB) HNMR (113 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4975 mL 17.4874 mL 34.9748 mL 87.4370 mL
5 mM 0.6995 mL 3.4975 mL 6.9950 mL 17.4874 mL
10 mM 0.3497 mL 1.7487 mL 3.4975 mL 8.7437 mL
15 mM 0.2332 mL 1.1658 mL 2.3317 mL 5.8291 mL
20 mM 0.1749 mL 0.8744 mL 1.7487 mL 4.3719 mL
25 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4975 mL
30 mM 0.1166 mL 0.5829 mL 1.1658 mL 2.9146 mL
40 mM 0.0874 mL 0.4372 mL 0.8744 mL 2.1859 mL
50 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7487 mL
60 mM 0.0583 mL 0.2915 mL 0.5829 mL 1.4573 mL
80 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0930 mL
100 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8744 mL
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1,3-Dibromo-5,5-dimethylhydantoin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3-Dibromo-5,5-dimethylhydantoin77-48-5PROTAC LinkersInhibitorinhibitorinhibit

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