2. Metabolic Enzyme/Protease
  3. Epoxide Hydrolase
  4. 1,3-Dicyclohexylurea

1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats.

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1,3-Dicyclohexylurea Chemical Structure

1,3-Dicyclohexylurea Chemical Structure

CAS No. : 2387-23-7

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Based on 1 publication(s) in Google Scholar

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1,3-Dicyclohexylurea Related Antibodies

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Description

1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats[1].

In Vivo

1,3-Dicyclohexylurea (Sprague Dawley rats, 30 mg/kg, Orally, once) shows antihypertensive efficacy when milled to reduce particle size, thus improving dissolution and oral bioavailability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

224.34

Formula

C13H24N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CCCCC1)NC2CCCCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (22.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4575 mL 22.2876 mL 44.5752 mL
5 mM 0.8915 mL 4.4575 mL 8.9150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (245 KB) HNMR (120 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4575 mL 22.2876 mL 44.5752 mL 111.4380 mL
5 mM 0.8915 mL 4.4575 mL 8.9150 mL 22.2876 mL
10 mM 0.4458 mL 2.2288 mL 4.4575 mL 11.1438 mL
15 mM 0.2972 mL 1.4858 mL 2.9717 mL 7.4292 mL
20 mM 0.2229 mL 1.1144 mL 2.2288 mL 5.5719 mL
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1,3-Dicyclohexylurea Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3-Dicyclohexylurea2387-23-7Epoxide HydrolaseOrally activeAntihypertensive effectNanosuspensionNanoparticle drug delivery systemSpontaneously hypertensive ratsInhibitorinhibitorinhibit

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