1-(4-Chlorobenzhydryl)piperazine

Name: 1-(4-Chlorobenzhydryl)piperazine
Brand: MedChemExpress
SKU: HY-W001978
Rating: 4.5 (1 reviews)

Cat. No.: HY-W001978 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions

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1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

1-(4-Chlorobenzhydryl)piperazine Chemical Structure

CAS No. : 303-26-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 30	Get quote	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

1-(4-Chlorobenzhydryl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

1-(4-Chlobenzhydryl)piperazine is an inactive metabolite of meclizine and chlorcyclizine. It has also been found as an impurity in commercial preparations of hydroxyzine and cetirizine. 1-(4-Chlorobenzhydryl)piperazine has been used in the synthesis of voltage-gated sodium channel 1.7 (Nav1.7) inhibitors, anticancer agents, and antihistamines.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.80

Formula

C₁₇H₁₉ClN₂

CAS No.

303-26-4

Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC=C(C(N2CCNCC2)C3=CC=CC=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (435.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4868 mL	17.4338 mL	34.8675 mL
5 mM	0.6974 mL	3.4868 mL	6.9735 mL
10 mM	0.3487 mL	1.7434 mL	3.4868 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (274 KB) SDS (718 KB)

COA (250 KB) HNMR (250 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Gaertner, HJ, Breyer, U., and Liomin, G.Chronic administration of chlorcyclizine and meclizine to rats: Accumulation of a metabolite formed by piperazine ring cleavage J. Pharmacol. Exp. Ther.185(2)195-201(1973)

[2]. Kuntzman, R., Klutch, A., Tsai, I., et al.Physiological distribution and metabolic inactivation of chlorcyclizine and cyclizineJ. Pharmacol. Exp. Ther.149(1)29-35(1965)

[3]. Simpson, D., Skellern, GG, and Miller, JHMethod for the control of known impurities in hydroxyzine hydrochlorideJ. Pharm . Biomed. Anal.14(8-10)1371-1375(1996)

[4]. Javid, FS, Shafaat, A., and Zarghi, A. Determination of cetirizine and its impurities in bulk and tablet formulation using a validated capillary zone electrophoretic methodJ. Anal. Chem.69(5)442-447(2014)

[5]. Back, SK, Kam, YL, Oh, JA, et al.Synthesis and evaluation of (4-chlorobenzhydryl) piperazine amides as sodium channel Nav7 inhibitorsBull. Korean Chem. Soc.36(9)2290-2297(2015)

[6]. Yarim, M., Koksal, M., Durmaz, I., et al.Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4 -(4-chlorobenzhydryl)piperazine derivativesInt. J. Mol. Sci.13(7)8071-8085(2012)

[7]. Narsaiah, AV, and Narssimha, P.Efficient synthesis of antihistamines clocinizine and chlorcyclizineMed. Chem. Res.21538- 541 (2012)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4868 mL	17.4338 mL	34.8675 mL	87.1688 mL
	5 mM	0.6974 mL	3.4868 mL	6.9735 mL	17.4338 mL
	10 mM	0.3487 mL	1.7434 mL	3.4868 mL	8.7169 mL
	15 mM	0.2325 mL	1.1623 mL	2.3245 mL	5.8113 mL
	20 mM	0.1743 mL	0.8717 mL	1.7434 mL	4.3584 mL
	25 mM	0.1395 mL	0.6974 mL	1.3947 mL	3.4868 mL
	30 mM	0.1162 mL	0.5811 mL	1.1623 mL	2.9056 mL
	40 mM	0.0872 mL	0.4358 mL	0.8717 mL	2.1792 mL
	50 mM	0.0697 mL	0.3487 mL	0.6974 mL	1.7434 mL
	60 mM	0.0581 mL	0.2906 mL	0.5811 mL	1.4528 mL
	80 mM	0.0436 mL	0.2179 mL	0.4358 mL	1.0896 mL
	100 mM	0.0349 mL	0.1743 mL	0.3487 mL	0.8717 mL