1-Methyladenosine-d₃ hydrochloride

Cat. No.: HY-113081AS: FAQs
Data Sheet Handling Instructions

Molarity Calculator

1-Methyladenosine-d3 hydrochloride is the hydrochloride salt form of deuterium labeled 1-Methyladenosine (HY-113081). 1-Methyladenosine is an RNA modification that can serve as a tumor marker, with elevated levels in the body associated with cancer development. Following 1-methyladenosine methylation, upregulation of PPARδ expression regulates cholesterol metabolism and activates Hedgehog signaling pathway, driving liver tumorigenesis.

For research use only. We do not sell to patients.

1-Methyladenosine-d<sub>3</sub> hydrochloride Chemical Structure

1-Methyladenosine-d₃ hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1200	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Other Forms of 1-Methyladenosine-d₃ hydrochloride:

1-Methyladenosine In-stock
1-Methyladenosine-d₃ Get quote

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•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

320.75

Formula

C₁₁H₁₃D₃ClN₅O₄

Appearance

Solid

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN(C([2H])([2H])[2H])C3=N)O[C@@H]1CO.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (155.88 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1177 mL	15.5885 mL	31.1769 mL
5 mM	0.6235 mL	3.1177 mL	6.2354 mL
10 mM	0.3118 mL	1.5588 mL	3.1177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Hauenschild R, et al. The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent. Nucleic Acids Res. 2015 Nov 16;43(20):9950-64. [Content Brief]

[3]. Banys K, et al. Effect of Genistein Supplementation on the Progression of Neoplasms and the Level of the Modified Nucleosides in Rats With Mammary Cancer. In Vivo. 2021 Jul-Aug;35(4):2059-2072. [Content Brief]

[4]. Wang Y, et al. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism[J]. Nature communications, 2021, 12(1): 6314. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1177 mL	15.5885 mL	31.1769 mL	77.9423 mL
	5 mM	0.6235 mL	3.1177 mL	6.2354 mL	15.5885 mL
	10 mM	0.3118 mL	1.5588 mL	3.1177 mL	7.7942 mL
	15 mM	0.2078 mL	1.0392 mL	2.0785 mL	5.1962 mL
	20 mM	0.1559 mL	0.7794 mL	1.5588 mL	3.8971 mL
	25 mM	0.1247 mL	0.6235 mL	1.2471 mL	3.1177 mL
	30 mM	0.1039 mL	0.5196 mL	1.0392 mL	2.5981 mL
	40 mM	0.0779 mL	0.3897 mL	0.7794 mL	1.9486 mL
	50 mM	0.0624 mL	0.3118 mL	0.6235 mL	1.5588 mL
	60 mM	0.0520 mL	0.2598 mL	0.5196 mL	1.2990 mL
	80 mM	0.0390 mL	0.1949 mL	0.3897 mL	0.9743 mL
	100 mM	0.0312 mL	0.1559 mL	0.3118 mL	0.7794 mL