2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine 

Cat. No.: HY-W355700 Purity: 98.95%
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COA
Handling Instructions Technical Support

1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction.

For research use only. We do not sell to patients.

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Chemical Structure

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Chemical Structure

CAS No. : 89576-29-4

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Based on 1 publication(s) in Google Scholar

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Antibodies

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Description

1-oleoyl-sn-glycero-3-phosphoethanolamine (LysoPE 18:1) is a lysophosphatidylethanolamine molecule involved in phospholipid metabolism, targeting cell membrane receptors (such as G protein-coupled receptors) to regulate cell signaling pathways. 1-oleoyl-sn-glycero-3-phosphoethanolamine may activate mitogen-activated protein kinase (MAPK) signaling, promote cell migration, regulate inflammatory responses and lipid metabolism, and has both pro-inflammatory and anti-inflammatory activities. 1-oleoyl-sn-glycero-3-phosphoethanolamine is mainly used in the screening of biomarkers for metabolic diseases (such as non-alcoholic fatty liver disease and obesity), as well as the study of the mechanism of lysophospholipids in cell membrane homeostasis and signal transduction[1][2].

In Vitro

The serum concentration of 1-oleoyl-sn-glycero-3-phosphoethanolamine in patients with non-alcoholic fatty liver disease (NAFLD) is significantly lower than that in the healthy control group. The total lysophosphatidylethanolamine (LysoPEs) concentrations in the simple steatosis (SS) and non-alcoholic steatohepatitis (NASH) groups are also lower than those in the healthy group, indicating that 1-oleoyl-sn-glycero-3-phosphoethanolamine can be used as a biomarker for NAFLD for disease identification and analysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Antibodies
Molecular Weight

479.59

Formula

C23H46NO7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)COP(OCCN)(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 2 mg/mL (4.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0851 mL 10.4256 mL 20.8511 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥99.0%

SDS (645 KB)

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.0851 mL 10.4256 mL 20.8511 mL 52.1279 mL
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1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Oleoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine89576-29-4Drug MetaboliteInhibitorinhibitorinhibit

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