10-Undecenoic acid zinc salt  (Synonyms: Zinc undecylenate)

10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa^{[1][2][3][4][5][6][7][8]}.

Preparations (1.6-3.8 mM; 3-6 h) of 10-Undecenoic acid zinc salt complexed with L-arginine induces apoptosis in tumor cells (A549 and Jurkat)^[2].
10-Undecenoic acid zinc salt (24 h) shows dose-dependent cytotoxicity to human tumor cell lines HeLa, A549, Jurkat, and U937, with IC₅₀s of 0.9862, 0.3751, 0.5782, 0.2893 mM, respectively^[2].
10-Undecenoic acid zinc salt (up to 5 μM) significantly increases the expression and activity of alkaline phosphatase and calcium deposition, and induces the expression of the osteocalcin gene in mouse osteoblastic MC3T3-E1 subclone 4 cells and primary mouse calvarial cells^[3].
10-Undecenoic acid zinc salt reduces the number of viable and active cells and makes the biofilm thinner in C. albicans biofilms, while it increases the cell count, metabolic activity and proteinase activity in C. glabrata biofilms^[4].
10-Undecenoic acid zinc salt (20 μM) shows neuroprotective effect against glutamate, H₂O₂ and Aβ_1-42 induced cell death in SH-SY5Y cells^[5].
10-Undecenoic acid zinc salt (1-40 mM; 6-24 h) reduces the cell death induced by H₂O₂, partially attenuates the cell death induced by Staurosporine (HY-15141) and Ddoxorubicin (HY-15142A) in SH-SY5Y cells^[6].
10-Undecenoic acid zinc salt (12.5-50 μg/mL) causes a reduction of LuxS/AI-2QS system in B. subtilis, and (15.625-250 μg/mL) causes a 10-54% reduction of LasI/LasR QS system in P. aeruginosa^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10-Undecenoic acid zinc salt (arginine undecylenate (GS-1) form, 157.6 mg/mL; topical administration; twice a day; 6 days) effectively clears MRSA infections in the epidermal and dermal layers in a rat model of MRSA skin infection^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

431.91

C₂₂H₃₈O₄Zn

557-08-4

Solid

White to off-white

C=CCCCCCCCCC([O-])=O.C=CCCCCCCCCC([O-])=O.[Zn+2]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Brayden DJ, et al. Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 2014 Sep;16(5):1064-76.  [Content Brief]

  [2]. Day ZI, et al. Novel Formulation of Undecylenic Acid induces Tumor Cell Apoptosis. Int J Mol Sci. 2022 Nov 16;23(22):14170.  [Content Brief]

  [3]. Kim MH, et al. Stimulatory effect of undecylenic acid on mouse osteoblast differentiation. Phytother Res. 2010 Apr;24(4):559-64.  [Content Brief]

  [4]. Gonçalves LM, et al. Effects of undecylenic acid released from denture liner on Candida biofilms. J Dent Res. 2012 Oct;91(10):985-9.  [Content Brief]

  [5]. Lee E, et al. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. Eur J Pharm Sci. 2012 May 12;46(1-2):17-25.  [Content Brief]

  [6]. Jantas D, et al. An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. J Cell Biochem. 2015 Dec;116(12):2882-95.  [Content Brief]

  [7]. Fernandes S, et al. Curcumin and 10-Undecenoic acid zinc salt as natural quorum sensing inhibitors of LuxS/AI-2 of Bacillus subtilis and LasI/LasR of Pseudomonas aeruginosa. Food Res Int. 2023 Mar;165:112519.  [Content Brief]

  [8]. Mayfosh A, et al. A Novel Ammonium Carboxylate Salt of Undecylenic Acid for the Topical Treatment of Gram-Positive and Antibiotic-Resistant Skin Infections. Exp Dermatol. 2025 Mar;34(3):e70075.  [Content Brief]