2. Anti-infection Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Fungal Amyloid-β Reactive Oxygen Species Proteasome Bacterial
  4. 10-Undecenoic acid,98% (stabilized with TBC)

10-Undecenoic acid,98% (stabilized with TBC)  (Synonyms: Undecylenic acid)

Cat. No.: HY-B0914 Purity: ≥98.0%
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10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

10-Undecenoic acid,98% (stabilized with TBC) Chemical Structure

10-Undecenoic acid,98% (stabilized with TBC) Chemical Structure

CAS No. : 112-38-9

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Based on 2 publication(s) in Google Scholar

Other Forms of 10-Undecenoic acid,98% (stabilized with TBC):

10-Undecenoic acid,98% (stabilized with TBC) Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE 10-Undecenoic acid,98% (stabilized with TBC)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa[1][2][3][4][5][6][7][8].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Preparations (1.6-3.8 mM; 3-6 h) of 10-Undecenoic acid complexed with L-arginine induces apoptosis in tumor cells (A549 and Jurkat)[2].
10-Undecenoic acid (24 h) shows dose-dependent cytotoxicity to human tumor cell lines HeLa, A549, Jurkat, and U937, with IC50s of 0.9862, 0.3751, 0.5782, 0.2893 mM, respectively[2].
10-Undecenoic acid (up to 5 μM) significantly increases the expression and activity of alkaline phosphatase and calcium deposition, and induces the expression of the osteocalcin gene in mouse osteoblastic MC3T3-E1 subclone 4 cells and primary mouse calvarial cells[3].
10-Undecenoic acid reduces the number of viable and active cells and makes the biofilm thinner in C. albicans biofilms, while it increases the cell count, metabolic activity and proteinase activity in C. glabrata biofilms[4].
10-Undecenoic acid (20 μM) shows neuroprotective effect against glutamate, H2O2 and Aβ1-42 induced cell death in SH-SY5Y cells[5].
10-Undecenoic acid (1-40 mM; 6-24 h) reduces the cell death induced by H2O2, partially attenuates the cell death induced by Staurosporine (HY-15141) and Ddoxorubicin (HY-15142A) in SH-SY5Y cells[6].
10-Undecenoic acid (12.5-50 μg/mL) causes a reduction of LuxS/AI-2QS system in B. subtilis, and (15.625-250 μg/mL) causes a 10-54% reduction of LasI/LasR QS system in P. aeruginosa[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10-Undecenoic acid,98% (stabilized with TBC) Related Antibodies

Cell Differentiation Assay[3]

Cell Line: Mouse osteoblastic MC3T3-E1 subclone 4 cells, primary mouse calvarial cells
Concentration: 2.5 μM, 5 μM
Incubation Time: During osteoblast differentiation (up to 18 days for some assays)
Result: Significantly increased the expression and activity of alkaline phosphatase at day 9 of differentiation (MC3T3-E1 subclone 4 cells).
Induced mineralization at day 15 and 18 (MC3T3-E1 subclone 4 cells).
Significantly induced calcium deposition at differentiation day 28 (primary mouse calvarial cells).
Regulated the mRNA expression levels of osteocalcin (OCN), Fra-2 and NFATc1 in both cell types.
In Vivo

10-Undecenoic acid (arginine undecylenate (GS-1) form, 157.6 mg/mL; topical administration; twice a day; 6 days) effectively clears MRSA infections in the epidermal and dermal layers in a rat model of MRSA skin infection[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

184.28

Formula

C11H20O2
CAS No.
Appearance

<23°C Solid,>25°C Liquid

Color

Off-white to light yellow

SMILES

C=CCCCCCCCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (271.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4266 mL 27.1328 mL 54.2655 mL
5 mM 1.0853 mL 5.4266 mL 10.8531 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4266 mL 27.1328 mL 54.2655 mL 135.6639 mL
5 mM 1.0853 mL 5.4266 mL 10.8531 mL 27.1328 mL
10 mM 0.5427 mL 2.7133 mL 5.4266 mL 13.5664 mL
15 mM 0.3618 mL 1.8089 mL 3.6177 mL 9.0443 mL
20 mM 0.2713 mL 1.3566 mL 2.7133 mL 6.7832 mL
25 mM 0.2171 mL 1.0853 mL 2.1706 mL 5.4266 mL
30 mM 0.1809 mL 0.9044 mL 1.8089 mL 4.5221 mL
40 mM 0.1357 mL 0.6783 mL 1.3566 mL 3.3916 mL
50 mM 0.1085 mL 0.5427 mL 1.0853 mL 2.7133 mL
60 mM 0.0904 mL 0.4522 mL 0.9044 mL 2.2611 mL
80 mM 0.0678 mL 0.3392 mL 0.6783 mL 1.6958 mL
100 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3566 mL
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10-Undecenoic acid,98% (stabilized with TBC) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Undecenoic acid,98% (stabilized with TBC)112-38-9Undecylenic acidFungalAmyloid-βReactive Oxygen SpeciesProteasomeBacterialβ-amyloid peptideAβAbetaHeLaA549Jurkat U937anticancerantifungalneuroprotectiveInhibitorinhibitorinhibit

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