11-Oxo etiocholanolone-d₅  (Synonyms: 11-Ketoetiocholanolone-d₅)

11-Oxo etiocholanolone-d₅ is the deuterium labeled 11-Oxo etiocholanolone. 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

309.45

C₁₉H₂₃D₅O₃

739-27-5

C[C@@]([C@](C1)([H])CC2)(CC[C@H]1O)[C@](C(C3([2H])[2H])=O)([2H])[C@]2([H])[C@@](CC([2H])([2H])C4=O)([H])[C@]34C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Wesley J Arbuckle, et al. In Vitro Biosynthesis of Novel 5beta-reduced Steroids by the Testis of the Round Goby, Neogobius Melanostomus. Gen Comp Endocrinol. 2005 Jan 1;140(1):1-13.  [Content Brief]

  [3]. Ping Li,et al. Natural and Enantiomeric Etiocholanolone Interact With Distinct Sites on the Rat alpha1beta2gamma2L GABAA Receptor. Mol Pharmacol. 2007 Jun;71(6):1582-90.  [Content Brief]