15-Keto-prostaglandin E2-d₄

Cat. No.: HY-113205S1: FAQs
Data Sheet Handling Instructions Technical Support

15-Keto-prostaglandin E2-d₄ is the deuterium labeled 15-Keto-prostaglandin E2[1].

For research use only. We do not sell to patients.

15-Keto-prostaglandin E2-d<sub>4</sub> Chemical Structure

15-Keto-prostaglandin E2-d₄ Chemical Structure

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of 15-Keto-prostaglandin E2-d₄:

15-keto-Prostaglandin E2 Get quote

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Biological Activity
Purity & Documentation
References
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Description

15-Keto-prostaglandin E2-d₄ is the deuterium labeled 15-Keto-prostaglandin E2[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

354.47

Formula

C₂₀H₂₆D₄O₅

Unlabeled CAS

26441-05-4

SMILES

O=C1[C@@H]([C@H]([C@@H](C1)O)/C=C/C(CCCCC)=O)C/C=C\C([2H])(C([2H])(CC(O)=O)[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (282.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8211 mL	14.1056 mL	28.2111 mL
5 mM	0.5642 mL	2.8211 mL	5.6422 mL
10 mM	0.2821 mL	1.4106 mL	2.8211 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8211 mL	14.1056 mL	28.2111 mL	70.5278 mL
	5 mM	0.5642 mL	2.8211 mL	5.6422 mL	14.1056 mL
	10 mM	0.2821 mL	1.4106 mL	2.8211 mL	7.0528 mL
	15 mM	0.1881 mL	0.9404 mL	1.8807 mL	4.7019 mL
	20 mM	0.1411 mL	0.7053 mL	1.4106 mL	3.5264 mL
	25 mM	0.1128 mL	0.5642 mL	1.1284 mL	2.8211 mL
	30 mM	0.0940 mL	0.4702 mL	0.9404 mL	2.3509 mL
	40 mM	0.0705 mL	0.3526 mL	0.7053 mL	1.7632 mL
	50 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4106 mL
	60 mM	0.0470 mL	0.2351 mL	0.4702 mL	1.1755 mL
	80 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8816 mL
	100 mM	0.0282 mL	0.1411 mL	0.2821 mL	0.7053 mL