2. Immunology/Inflammation Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. COX Lipoxygenase Interleukin Related PPAR
  4. 15-LOX-IN-2

15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases.

For research use only. We do not sell to patients.

15-LOX-IN-2 Chemical Structure

15-LOX-IN-2 Chemical Structure

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15-LOX-IN-2 Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

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5-LOX 12-LOX 15-LOX

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases[1].

IC50 & Target[1]

COX-2

0.190 μM (IC50)

IL-1β

 

15-LOX

5.87 μM (IC50)

COX-1

7.510 μM (IC50)

PPARγ

 

Molecular Weight

312.39

Formula

C17H16N2O2S
SMILES

O=C1N=C(N2CCCC2)S/C1=C\C3=CC=C(OCC#C)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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15-LOX-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-LOX-IN-2COXLipoxygenaseInterleukin RelatedPPARCyclooxygenaseLOXILPeroxisome proliferator-activated receptorsRAW264.7HEK293TDiabetes modelInhibitorinhibitorinhibit

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