16,16-Dimethylprostaglandin E1  (Synonyms: 16,16-dimethyl-PGE1)

16,16-Dimethylprostaglandin E1 (16,16-dimethyl-PGE1) is a PGE1 (HY-B0131) analog, induces bronchoconstrict and vascular smooth muscle contractions and suppresses the indomethacin induced cellular elongation^[1][2][3].

16,16-Dimethylprostaglandin E1 (1 μg/kg•min for 30 min) accelerates blood pressure and heart rate recovery rate, increases catecholamine turnover, enhances levels of epinephrine and norepinephrine in plasma following acute hemorrhage in Sprague Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

382.53

C₂₂H₃₈O₅

41692-15-3

CCCCC(C)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Feuerstein G, et al., Prostaglandins, catecholamines, and cardiovascular responses to hemorrhage. Am J Physiol. 1981 Mar;240(3):R166-74.  [Content Brief]

  [2]. Jumblatt MM, et al., Prostaglandin E2 effects on corneal endothelial cyclic adenosine monophosphate synthesis and cell shape are mediated by a receptor of the EP2 subtype. Invest Ophthalmol Vis Sci. 1991 Feb;32(2):360-5.  [Content Brief]

  [3]. Strandberg K, et al., Bronchial effects of some prostaglandin E and F analogues. Acta Physiol Scand. 1977 Jun;100(2):172-81.  [Content Brief]