2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Na+/K+ ATPase Cytochrome P450
  4. 17-HETE

17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy.

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17-HETE Chemical Structure

17-HETE Chemical Structure

CAS No. : 128914-47-6

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Based on 1 publication(s) in Google Scholar

Other Forms of 17-HETE:

17-HETE Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2].

IC50 & Target

CYP1B1

 

In Vitro

17-HETE (5-20 μM) promotes the development of cardiac hypertrophy in human, through increasing CY1B1 at activity and protein levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

17-HETE Related Antibodies

Real Time qPCR[1]

Cell Line: AC16
Concentration: 5-20 µM
Incubation Time: 24 h
Result: Increased mRNA levels of β-MHC and ANP, increased cell surface area.

Western Blot Analysis[1]

Cell Line: AC16
Concentration: 20 µM
Incubation Time: 24 h
Result: Increased expression of CYP 1B1.
In Vivo

17-HETE (1-20 μg, i.a.) stereospecificially inhibits proximal tubule ATPase activity with S- enantiomer in New Zealand white rabbit[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbit[2]
Dosage: 1-20 μg
Administration: injection into artery
Result: 17S inhibited more than 70% ATPase activity at the concentration of 2 μM, while 17R enantiomer remained inactive.
Molecular Weight

320.47

Formula

C20H32O3
CAS No.
SMILES

CCCC(C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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17-HETE Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17-HETE128914-47-6Na+/K+ ATPaseCytochrome P450Sodium potassium pumpCYPscardiac hypertrophyAC16Inhibitorinhibitorinhibit

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HY-116196
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