2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (Synonyms: DDD; Bis(6-hydroxy-2-naphthyl)disulfide; PIR-3.5)

Cat. No.: HY-110085: FAQs
Data Sheet Handling Instructions

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2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (PIR-3.5) is a PAK1 inhibitor.

For research use only. We do not sell to patients.

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Chemical Structure

CAS No. : 6088-51-3

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

Biological Activity
Purity & Documentation
References
Customer Review

Description

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (PIR-3.5) is a PAK1 inhibitor^[1].

IC₅₀ & Target

PAK1

In Vitro

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide (PIR-3.5) (20 μM; 24 h) does not affect cell viability in primary human schwannoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.45

Formula

C₂₀H₁₄O₂S₂

CAS No.

6088-51-3

SMILES

OC1=CC=C(C(C=C2)=C1)C=C2SSC3=CC4=CC=C(O)C=C4C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Flaiz C, et al. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol. 2009;218(1):137-144. [Content Brief]

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,2′-Dihydroxy-6,6′-dinaphthyl disulfide6088-51-3DDD Bis(6-hydroxy-2-naphthyl)disulfide PIR-3.5PAKp21 activated kinasesschwannomaInhibitorinhibitorinhibit

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