2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. DL-Homocysteine

DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity.

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DL-Homocysteine Chemical Structure

DL-Homocysteine Chemical Structure

CAS No. : 454-29-5

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10 mM * 1 mL in Water
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Based on 2 publication(s) in Google Scholar

DL-Homocysteine Related Antibodies

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Description

DL-Homocysteine is a weak neurotoxin, and can affect the production of kynurenic acid in the brain. DL-Homocysteine is correlated with Vitamin B12, renal functions and folate levels, affects the cross-sectional cognition indirectly through white matter microstructural integrity[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Homocysteine Related Antibodies
In Vivo

DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

135.19

Formula

C4H9NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N)CCS
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 41.67 mg/mL (308.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3971 mL 36.9855 mL 73.9711 mL
5 mM 1.4794 mL 7.3971 mL 14.7942 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.97%

SDS (562 KB)

COA (244 KB) HNMR (131 KB) RP-HPLC (194 KB) LCMS (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.3971 mL 36.9855 mL 73.9711 mL 184.9277 mL
5 mM 1.4794 mL 7.3971 mL 14.7942 mL 36.9855 mL
10 mM 0.7397 mL 3.6986 mL 7.3971 mL 18.4928 mL
15 mM 0.4931 mL 2.4657 mL 4.9314 mL 12.3285 mL
20 mM 0.3699 mL 1.8493 mL 3.6986 mL 9.2464 mL
25 mM 0.2959 mL 1.4794 mL 2.9588 mL 7.3971 mL
30 mM 0.2466 mL 1.2329 mL 2.4657 mL 6.1643 mL
40 mM 0.1849 mL 0.9246 mL 1.8493 mL 4.6232 mL
50 mM 0.1479 mL 0.7397 mL 1.4794 mL 3.6986 mL
60 mM 0.1233 mL 0.6164 mL 1.2329 mL 3.0821 mL
80 mM 0.0925 mL 0.4623 mL 0.9246 mL 2.3116 mL
100 mM 0.0740 mL 0.3699 mL 0.7397 mL 1.8493 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DL-Homocysteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Homocysteine454-29-5Endogenous MetaboliteAlzheimer’s diseaserenal dysfunctionVitamin B12folatewhite matterInhibitorinhibitorinhibit

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