2-Chloro-ADP sodium  (Synonyms: 2-Chloroadenosine 5′-diphosphate sodium)

2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) sodium is a Adenosine 5'-diphosphate (ADP; HY-W010918) derivative that induces human platelet aggregation and inhibits stimulated adenylate cyclase^[1]. 2-Chloro-ADP sodium inhibits mortalin nucleotide-binding domain (NBD) with a K_i of 45.05 μM^[2].

527.59

C₁₀H₁₁ClN₅Na₃O₁₀P₂

82927-78-4

O[C@H]1[C@@H](O)[C@H](N2C3=NC(Cl)=NC(N)=C3N=C2)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O

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• [1]. N J Cusack, et al. Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate. Br J Pharmacol. 1982 Oct;77(2):329-33.  [Content Brief]

  [2]. Mitchell A Moseng, et al. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. FEBS Lett. 2019 Aug;593(15):2030-2039.  [Content Brief]