2-Deoxy-D-glucose-¹³C₆  (Synonyms: 2-DG-¹³C₆; 2-Deoxy-D-arabino-hexose-¹³C₆; D-Arabino-2-deoxyhexose-¹³C₆)

2-Deoxy-D-glucose-¹³C₆ (2-DG-¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase^[1][2].

170.11

¹³C₆H₁₂O₅

201740-77-4

154-17-6

O=[13CH][13CH2][13C@@H](O)[13C@H](O)[13C@H](O)[13CH2]O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29(5):2053-7.  [Content Brief]

  [3]. Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65(15):7023-30.  [Content Brief]

  [4]. Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo. Biol Signals Recept. 2000 Sep-Oct;9(5):267-74.  [Content Brief]