2-Deoxy-D-glucose 6-phosphate

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2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) . 2-Deoxy-D-glucose is incorporated into glycogen.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (2-Deoxy-D-glucose 6-phosphate disodium) usually boasts enhanced water solubility and stability.

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2-Deoxy-D-glucose 6-phosphate Chemical Structure

CAS No. : 3573-50-0

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Other Forms of 2-Deoxy-D-glucose 6-phosphate:

2-Deoxy-D-glucose 6-phosphate disodium Get quote

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Description	2-Deoxy-D-glucose 6-phosphate is an intermediate of 2-deoxy-D-glucose (2-DG) ^[1]. 2-Deoxy-D-glucose is incorporated into glycogen^[2].
In Vitro	Acting as a D-glucose mimic, 2-deoxy-D-glucose (2-DG) inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-D-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death^[3]. The accumulation of 2-deoxyglucose-6-phosphate (2-DG6P), detected using 31P nuclear magnetic resonance spectroscopy, is used to assess glucose uptake before and during insulin stimulation in the isolated perfused heart^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 2-Deoxy-D-glucose 6-phosphate Related Antibodies
Molecular Weight	244.14
Formula	C₆H₁₃O₈P
CAS No.	3573-50-0
SMILES	O=P(O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)CC=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429. [Content Brief] [2]. Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604. [Content Brief] [3]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29. [Content Brief] [4]. Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211. [Content Brief]