2'-F-2'-ara-N2-ibu-dG Phosphoramidite

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2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).

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2'-F-2'-ara-N2-ibu-dG Phosphoramidite Chemical Structure

CAS No. : 1404463-20-2

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Description	2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)^[1].
Molecular Weight	856.92
Formula	C₄₅H₅₄FN₆O₈P
CAS No.	1404463-20-2
SMILES	O=C1NC(NC(C(C)C)=O)=NC2=C1N=CN2[C@@H]3O[C@H](COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)[C@@H](OP(OCCC#N)C(C(C)C)C(C)C)[C@@H]3F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. [Content Brief]