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  4. 2-Hydroxy-3-methoxychalcone

2-Hydroxy-3-methoxychalcone is a methoxy-derivative of 2'-Hydroxychalcone with an anticancer activity.

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2-Hydroxy-3-methoxychalcone Chemical Structure

2-Hydroxy-3-methoxychalcone Chemical Structure

CAS No. : 7146-86-3

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2-Hydroxy-3-methoxychalcone Related Antibodies

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Description

2-Hydroxy-3-methoxychalcone is a methoxy-derivative of 2'-Hydroxychalcone with an anticancer activity[1].

Cellular Effect
Cell Line Type Value Description References
Neutrophil IC50
3 μM
Compound: 10
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
Neutrophil IC50
5.7 μM
Compound: 10
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
[PMID: 33006891]
THP-1 CC50
> 25 μM
Compound: 1
Cytotoxicity against human THP1 cells by MTT assay
Cytotoxicity against human THP1 cells by MTT assay
[PMID: 28064141]
In Vitro

2-Hydroxy-3-methoxychalcone (TJ3) (10 µM and 25 µM) significantly reduces the concentration of MIF secreted by SW480 cells which correlates with downregulations of ICAM-1. 2-Hydroxy-3-methoxychalcone (25 µM) increases the concentration of IL-8 in SW480 and SW620 cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Hydroxy-3-methoxychalcone Related Antibodies
Molecular Weight

254.28

Formula

C16H14O3
CAS No.
SMILES

O=C(C1=CC=CC=C1O)C=CC2=CC=CC(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Hydroxy-3-methoxychalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Hydroxy-3-methoxychalcone7146-86-3Othersanticancer activitymethoxy-derivativeInhibitorinhibitorinhibit

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HY-W411442
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