2. NF-κB Anti-infection Apoptosis Autophagy
  3. NF-κB Fungal Apoptosis Autophagy
  4. 2′-Hydroxychalcone

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp.

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2′-Hydroxychalcone Chemical Structure

2′-Hydroxychalcone Chemical Structure

CAS No. : 1214-47-7

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2′-Hydroxychalcone Related Antibodies

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Description

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

In Vitro

2′-Hydroxychalcone (10-90 μM; 12-72 h) suppresses cell viability in a dose-dependent manner, with IC50 values of 37.74 μM and 34.26 μM for the two breast cancer cell lines MCF-7 and CMT-1211, respectively[1].
2′-Hydroxychalcone (10-30 μM; 24 h) promotes autophagy vesicle accumulation in breast cancer cells[1].
2′-Hydroxychalcone (30 μM; 24 h) induces autophagy-dependent apoptosis in breast cancer cells, and increases cleavage of caspase-3 and PARP[1].
2′-Hydroxychalcone (10-30 μM; 24 h) significantly reduces the expression of p-IκB and p-NF-κBp65, and elevates the levels of p-ERK and p-JNK[1].
2′-Hydroxychalcone (30 μM; 12-24 h) increased the intracellular ROS levels and triggered endoplasmic reticulum stress (ERS) of breast cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2′-Hydroxychalcone Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM, 70 μM, 80 μM, and 90 μM
Incubation Time: 12 h, 24 h, 36 h, 48 h, 60 h, and 72 h
Result: Suppressed cell viability in a dose-dependent manner.

Cell Autophagy Assay[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 h
Result: Induced autophagy and promoted autophagy flux in breast cancer cells.

Apoptosis Analysis[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 30 μM
Incubation Time: 24 h
Result: Induced autophagy-dependent apoptosis of breast cancer cells.

Western Blot Analysis[1]

Cell Line: MCF-7 and CMT-1211 cells
Concentration: 10 μM, 20 μM, 30 μM
Incubation Time: 24 h
Result: Regulated MAPK/NF-κB signaling pathways and inhibited migration/invasion of breast cancer cells.
In Vivo

2'-Hydroxychalcone (20-60 mg/kg; ip; every 2 days; 3 weeks) could exhibit an antitumor effect in vivo without causing significant toxicity to essential organs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old Balb/C female mice injected with CMT-1211 cells[1]
Dosage: 20 mg/kg, 40 mg/kg, 60 mg/kg
Administration: Intraperitoneal injection; every 2 days; 3 weeks
Result: Suppressed tumor growth and metastasis in vivo.
Molecular Weight

224.25

Formula

C15H12O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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2′-Hydroxychalcone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2′-Hydroxychalcone1214-47-7NF-κBFungalApoptosisAutophagyNuclear factor-κBNuclear factor-kappaBanticancer activitiesautophagyapoptosisantifungal activityInhibitorinhibitorinhibit

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