2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2-Methoxyestrone-d4

2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

For research use only. We do not sell to patients.

2-Methoxyestrone-d<sub>4</sub> Chemical Structure

2-Methoxyestrone-d4 Chemical Structure

CAS No. : 949885-90-9

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Methoxyestrone-d4:

2-Methoxyestrone-d4 Related Antibodies

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Description

2-Methoxyestrone-d4 is the deuterium labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Methoxyestrone-d4 Related Antibodies
Molecular Weight

304.42

Formula

C19H20D4O3
CAS No.
Unlabeled CAS

362-08-3
Appearance

Solid

Color

White to yellow

SMILES

C[C@@]12[C@](CC([2H])([2H])C2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=C([2H])C(OC)=C(O)C([2H])=C4CC3
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (164.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (164.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2849 mL 16.4247 mL 32.8493 mL
5 mM 0.6570 mL 3.2849 mL 6.5699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.2849 mL 16.4247 mL 32.8494 mL 82.1234 mL
5 mM 0.6570 mL 3.2849 mL 6.5699 mL 16.4247 mL
10 mM 0.3285 mL 1.6425 mL 3.2849 mL 8.2123 mL
15 mM 0.2190 mL 1.0950 mL 2.1900 mL 5.4749 mL
20 mM 0.1642 mL 0.8212 mL 1.6425 mL 4.1062 mL
25 mM 0.1314 mL 0.6570 mL 1.3140 mL 3.2849 mL
30 mM 0.1095 mL 0.5475 mL 1.0950 mL 2.7374 mL
40 mM 0.0821 mL 0.4106 mL 0.8212 mL 2.0531 mL
50 mM 0.0657 mL 0.3285 mL 0.6570 mL 1.6425 mL
60 mM 0.0547 mL 0.2737 mL 0.5475 mL 1.3687 mL
80 mM 0.0411 mL 0.2053 mL 0.4106 mL 1.0265 mL
100 mM 0.0328 mL 0.1642 mL 0.3285 mL 0.8212 mL
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2-Methoxyestrone-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methoxyestrone-d4949885-90-9Endogenous MetaboliteInhibitorinhibitorinhibit

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