2-Methylthio-AMP diTEA  (Synonyms: 2-MeSAMP diTEA; 2-Methylthioadenosine 5′-monophosphate diTEA; 2-Methylthioadenosine 5′-phosphate diTEA)

2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y₁₂ antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation^[1][2][3].

2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated α_IIbβ₃ activation in platelets^[1].
2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca²⁺ mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca²⁺ mobilization in P2Y₁₂-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

595.69

C₂₃H₄₆N₇O₇PS

1227193-98-7

Solid

White to light yellow

O[C@H]1[C@@H](O)[C@H](N2C3=NC(SC)=NC(N)=C3N=C2)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43.  [Content Brief]

  [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42.  [Content Brief]

  [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.  [Content Brief]