2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
  4. 2'-O,4'-C-Methyleneadenosine

2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.

For research use only. We do not sell to patients.

2'-O,4'-C-Methyleneadenosine Chemical Structure

2'-O,4'-C-Methyleneadenosine Chemical Structure

CAS No. : 206055-70-1

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2'-O,4'-C-Methyleneadenosine Related Antibodies

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Description

2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog[1].

Cellular Effect
Cell Line Type Value Description References
Huh-7 EC50
> 50 μM
Compound: 4
Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
[PMID: 24815510]
Molecular Weight

279.25

Formula

C11H13N5O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C(N=CN=C4N)=C4N=C3)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 5 mg/mL (17.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5810 mL 17.9051 mL 35.8102 mL
5 mM 0.7162 mL 3.5810 mL 7.1620 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5810 mL 17.9051 mL 35.8102 mL 89.5255 mL
5 mM 0.7162 mL 3.5810 mL 7.1620 mL 17.9051 mL
10 mM 0.3581 mL 1.7905 mL 3.5810 mL 8.9526 mL
15 mM 0.2387 mL 1.1937 mL 2.3873 mL 5.9684 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2'-O,4'-C-Methyleneadenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-O,4'-C-Methyleneadenosine206055-70-1LNA-ANucleoside Antimetabolite/AnalogDNA/RNA Synthesislocked nucleic acidLNAadenosine analogInhibitorinhibitorinhibit

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