2. Apoptosis
  3. Apoptosis
  4. 2-tert-Butyl-1,4-benzoquinone

2-tert-Butyl-1,4-benzoquinone is an electrophilic metabolite of butylated hydroxyanisole and an oxidation product of 2-tert-butylhydroquinone.

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2-tert-Butyl-1,4-benzoquinone Chemical Structure

2-tert-Butyl-1,4-benzoquinone Chemical Structure

CAS No. : 3602-55-9

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2-tert-Butyl-1,4-benzoquinone Related Antibodies

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Description

2-tert-Butyl-1,4-benzoquinone is an electrophilic metabolite of butylated hydroxyanisole and an oxidation product of 2-tert-butylhydroquinone[1].

Cellular Effect
Cell Line Type Value Description References
A2780 IC50
5.7 μM
Compound: 12
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
Growth inhibition of human A2780 cells after 72 hrs by SRB assay
[PMID: 29519737]
A2780cis IC50
4.9 μM
Compound: 12
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
Growth inhibition of human A2780cis cells after 72 hrs by SRB assay
[PMID: 29519737]
A549 IC50
47.02 μM
Compound: 2
Cytotoxicity against human A549 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
HaCaT IC50
95 μM
Compound: 1; TBHQ
Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells after 72 hrs by MTT assay
[PMID: 27128177]
HeLa IC50
44.08 μM
Compound: 2
Cytotoxicity against human HeLa cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
K562 IC50
15.54 μM
Compound: 2
Cytotoxicity against human K562 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
MDA-MB-453 IC50
56.83 μM
Compound: 2
Cytotoxicity against human MDA-MB-453 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-453 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
MRC5 IC50
> 200 μM
Compound: 2
Cytotoxicity against human MRC5 cells assessed as cell survival after 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as cell survival after 72 hrs by MTT assay
[PMID: 26476666]
NCI-H460 IC50
> 100 μM
Compound: 1; TBHQ
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 27128177]
NCI-H460 IC50
72 μM
Compound: 1; TBHQ
Cytotoxicity against multidrug resistant human NCI-H460 cells after 72 hrs by MTT assay
Cytotoxicity against multidrug resistant human NCI-H460 cells after 72 hrs by MTT assay
[PMID: 27128177]
OVCAR-8 IC50
10 μM
Compound: 12
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
Growth inhibition of human OVCAR8 cells after 72 hrs by SRB assay
[PMID: 29519737]
Molecular Weight

164.20

Formula

C10H12O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(C1=CC(C=CC1=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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2-tert-Butyl-1,4-benzoquinone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-tert-Butyl-1,4-benzoquinone3602-55-9Apoptosis1,4-benzoquinonederivativeelectrophilic metabolitebutylated hydroxyanisoleoxidation2-tert-butylhydroquinoneInhibitorinhibitorinhibit

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