1. GPCR/G Protein
  2. P2Y Receptor
  3. 2-Thio-UTP

2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

For research use only. We do not sell to patients.

2-Thio-UTP Chemical Structure

2-Thio-UTP Chemical Structure

CAS No. : 35763-29-2

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Description

2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].

IC50 & Target[1]

P2Y2 Receptor

50 nM (EC50)

In Vitro

2-Thio-UTP (10 µM; 5 days) reduces the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1 and reduces the protein of αSMA in valve interstitial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: valve interstitial cells
Concentration: 10 µM
Incubation Time: 5 days
Result: Reduced the αSMA protein expression.

RT-PCR[2]

Cell Line: valve interstitial cells
Concentration: 10 µM
Incubation Time: 5 days
Result: Significantly reduced the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1.
Molecular Weight

500.21

Formula

C9H15N2O14P3S

CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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2-Thio-UTP Related Classifications

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Product Name:
2-Thio-UTP
Cat. No.:
HY-116307
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