2-Thio-UTP

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2-Thio-UTP is a selective P2Y₂ inhibitor with an EC₅₀ value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .

For research use only. We do not sell to patients.

2-Thio-UTP Chemical Structure

CAS No. : 35763-29-2

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Other Forms of 2-Thio-UTP:

2-Thio-UTP tetrasodium Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

P2Y2 Receptor

50 nM (EC₅₀)

In Vitro

2-Thio-UTP (10 µM; 5 days) reduces the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1 and reduces the protein of αSMA in valve interstitial cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	valve interstitial cells
Concentration:	10 µM
Incubation Time:	5 days
Result:	Reduced the αSMA protein expression.

RT-PCR^[2]

Cell Line:	valve interstitial cells
Concentration:	10 µM
Incubation Time:	5 days
Result:	Significantly reduced the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1.

Molecular Weight

500.21

Formula

C₉H₁₅N₂O₁₄P₃S

CAS No.

35763-29-2

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [Content Brief]

[2]. Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10(2):457. [Content Brief]

2-Thio-UTP Related Classifications

Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Thio-UTP35763-29-2P2Y ReceptorαSMAcalcific aortic valve stenosisvalve interstitial cellsInhibitorinhibitorinhibit

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