21-Hydroxyoligomycin A

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21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC₅₀ value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces.

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21-Hydroxyoligomycin A Chemical Structure

CAS No. : 102042-09-1

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Description	21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC₅₀ value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces^[1].
In Vitro	21-Hydroxyoligomycin A is cytotoxic to SW620 and SW620 Ad300 cells with IC₅₀ values of 14.4 and 11.8 μM, respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 21-Hydroxyoligomycin A Related Antibodies
Molecular Weight	807.06
Formula	C₄₅H₇₄O₁₂
CAS No.	102042-09-1
SMILES	C[C@@H]([C@]1([H])OC(/C=C/[C@@H]([C@H]([C@@H](C([C@@H]([C@H]([C@@H]2C)O)C)=O)C)O)C)=O)[C@@](O[C@H]3C[C@H](O)C)(CC[C@@H]3C)O[C@](C[C@H]([C@H](/C=C/C=C\C[C@H]([C@@H]([C@@](O)(C2=O)C)O)C)CC)O)([H])[C@H]1C
Structure Classification	Antibiotics Macrolide Antibiotics
Initial Source	Microorganisms Streptomyces cyaneogriseus
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Salim AA, et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Org Biomol Chem. 2016 Jan 14;14(2):711-715. [Content Brief]