3,4-Dihydroxybenzeneacetic acid-d₅

Name: 3,4-Dihydroxybenzeneacetic acid-d 5
Brand: MedChemExpress
SKU: HY-W001080S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W001080S Purity: 99.50%: FAQs
Data Sheet SDS COA Handling Instructions

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3,4-Dihydroxybenzeneacetic acid-d₅ is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.

For research use only. We do not sell to patients.

3,4-Dihydroxybenzeneacetic acid-d<sub>5</sub> Chemical Structure

3,4-Dihydroxybenzeneacetic acid-d₅ Chemical Structure

CAS No. : 60696-39-1

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 3,4-Dihydroxybenzeneacetic acid-d₅:

3,4-Dihydroxybenzeneacetic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

3,4-Dihydroxybenzeneacetic acid-d₅ is the deuterium labeled 3,4-Dihydroxybenzeneacetic acid. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

173.18

Formula

C₈H₃D₅O₄

CAS No.

60696-39-1

Unlabeled CAS

102-32-9

Appearance

Solid

Color

Light brown to gray

SMILES

OC(C([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (577.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (288.72 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7743 mL	28.8717 mL	57.7434 mL
5 mM	1.1549 mL	5.7743 mL	11.5487 mL
10 mM	0.5774 mL	2.8872 mL	5.7743 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.50%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (252 KB) HNMR (223 KB) RP-HPLC (642 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Goldstein DS, et al. Elevated cerebrospinal fluid ratios of cysteinyl-dopamine/3,4-dihydroxyphenylacetic acid in parkinsonian synucleinopathies. Parkinsonism Relat Disord. 2016 Oct;31:79-86. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	5.7743 mL	28.8717 mL	57.7434 mL	144.3585 mL
	5 mM	1.1549 mL	5.7743 mL	11.5487 mL	28.8717 mL
	10 mM	0.5774 mL	2.8872 mL	5.7743 mL	14.4358 mL
	15 mM	0.3850 mL	1.9248 mL	3.8496 mL	9.6239 mL
	20 mM	0.2887 mL	1.4436 mL	2.8872 mL	7.2179 mL
	25 mM	0.2310 mL	1.1549 mL	2.3097 mL	5.7743 mL
	30 mM	0.1925 mL	0.9624 mL	1.9248 mL	4.8119 mL
	40 mM	0.1444 mL	0.7218 mL	1.4436 mL	3.6090 mL
	50 mM	0.1155 mL	0.5774 mL	1.1549 mL	2.8872 mL
	60 mM	0.0962 mL	0.4812 mL	0.9624 mL	2.4060 mL
	80 mM	0.0722 mL	0.3609 mL	0.7218 mL	1.8045 mL
	100 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4436 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.