2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 3’-beta-C-Methyladenosine

3′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).

For research use only. We do not sell to patients.

3’-beta-C-Methyladenosine Chemical Structure

3’-beta-C-Methyladenosine Chemical Structure

CAS No. : 15397-13-4

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3’-beta-C-Methyladenosine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

3′-β-C-Methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 GI50
23.2 μM
Compound: 3'-Me-Ado
Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay
Antitumor activity against human CaCo2 cells after 48 hrs by MTS assay
[PMID: 18588281]
Caco-2 GI50
24.3 μM
Compound: 3'-Me-Ado
Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay
Antiproliferative activity against human Caco2 cells after 72 hrs by MTS assay
[PMID: 21349610]
Caco-2 IC50
24.3 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
[PMID: 25304896]
HeLa GI50
23.3 μM
Compound: 3'-Me-Ado
Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay
[PMID: 21349610]
HeLa IC50
23.3 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
Growth inhibition of human HeLa cells after 48 hrs by MTT assay
[PMID: 25304896]
HL-60 IC50
15 μM
Compound: 5, 3'-Me-Ado
Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method
Cytotoxicity against human HL60 cells after 24 to 48 hrs by trypan blue dye exclusion method
[PMID: 25304896]
HL-60 IC50
15.6 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
Growth inhibition of human HL60 cells after 48 hrs by MTT assay
[PMID: 25304896]
HT-29 GI50
26.1 μM
Compound: 3'-Me-Ado
Antitumor activity against human HT29 cells after 48 hrs by MTS assay
Antitumor activity against human HT29 cells after 48 hrs by MTS assay
[PMID: 18588281]
HT-29 GI50
26.1 μM
Compound: 3'-Me-Ado
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
[PMID: 21349610]
HT-29 IC50
26.1 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
Growth inhibition of human HT-29 cells after 48 hrs by MTT assay
[PMID: 25304896]
HuT78 IC50
17.3 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human HUT78 cells after 48 hrs by MTT assay
Growth inhibition of human HUT78 cells after 48 hrs by MTT assay
[PMID: 25304896]
K562 GI50
9.4 μM
Compound: 3'-Me-Ado
Antitumor activity against human K562 cells after 48 hrs by MTS assay
Antitumor activity against human K562 cells after 48 hrs by MTS assay
[PMID: 18588281]
K562 GI50
9.4 μM
Compound: 3'-Me-Ado
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
[PMID: 21349610]
K562 IC50
9.4 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human K562 cells after 48 hrs by MTT assay
Growth inhibition of human K562 cells after 48 hrs by MTT assay
[PMID: 25304896]
MCF7 GI50
22.4 μM
Compound: 3'-Me-Ado
Antitumor activity against human MCF7 cells after 48 hrs by MTS assay
Antitumor activity against human MCF7 cells after 48 hrs by MTS assay
[PMID: 18588281]
MCF7 GI50
22.4 μM
Compound: 3'-Me-Ado
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21349610]
MCF7 IC50
22.4 μM
Compound: 5, 3'-Me-Ado
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
[PMID: 25304896]
Molecular Weight

281.27

Formula

C11H15N5O4
CAS No.
SMILES

C[C@]1(O)[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3’-beta-C-Methyladenosine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3’-beta-C-Methyladenosine15397-13-4Nucleoside Antimetabolite/Analogmuscle vasodilatorInhibitorinhibitorinhibit

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