BzATP triethylammonium (Synonyms: Benzoylbenzoyl-ATP triethylammonium)

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BzATP triethylammonium acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. BzATP triethylammonium is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively.

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BzATP triethylammonium Chemical Structure

CAS No. : 112898-15-4

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Other Forms of BzATP triethylammonium:

BzATP triethylammonium salt Get quote

1 Publications Citing Use of MCE BzATP triethylammonium

•Mol Med. 2019 Dec;20(6):5084-5090. [Abstract]

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P2X1 Receptor P2X2 Receptor P2X3 Receptor P2X4 Receptor P2X7 Receptor

Biological Activity
Purity & Documentation
References
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Description

BzATP triethylammonium acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively^[1]. BzATP triethylammonium is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively^[2].

IC₅₀ & Target

pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)^[1]
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)^[2]

In Vitro

BzATP (10-1000 μM; 24 h) triethylammonium promotes the proliferation and migration of U87 and U251 glioma cells^[3].
[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	U87 and U251 glioma cells
Concentration:	5, 10, 50, 100, 500 and 1000 μM
Incubation Time:	2, 6, 12, 24, 48 and 72 hours
Result:	The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively. The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines.

Western Blot Analysis^[3]

Cell Line:	U87 and U251 glioma cells
Concentration:	100 μM
Incubation Time:	6-48 hours
Result:	Induced the upregulation of P2X7R.

In Vivo

BzATP (5 mg/kg) triethylammonium significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g)^[4]
Dosage:	5 mg/kg
Administration:	Injected through the intraperitoneal route
Result:	At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.

Molecular Weight

816.58

Formula

C₃₀H₃₉N₆O₁₅P₃

CAS No.

112898-15-4

Appearance

Solid

Color

White to off-white

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](OC(C4=CC=C(C=C4)C(C5=CC=CC=C5)=O)=O)[C@H]3O)C=N2)=NC=N1.CCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. B R Bianchi, et al. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol. 1999 Jul 2;376(1-2):127-38. [Content Brief]

[2]. Mark T Young, et al. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol. 2007 Jan;71(1):92-100. [Content Brief]

[3]. Zhenhua Ji, et al. Involvement of P2X 7 Receptor in Proliferation and Migration of Human Glioma Cells. Biomed Res Int. 2018 Jan 9;2018:8591397. [Content Brief]

[4]. Xiuwen Wu, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Sci Rep. 2017 Jun 29;7(1):4364. [Content Brief]

BzATP triethylammonium Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BzATP112898-15-4Benzoylbenzoyl-ATPP2X ReceptorP2XRsP2X1P2X2P2X3P2X2/3P2X4P2X7inflammatoryOvarianCarcinomaInhibitorinhibitorinhibit

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