3-Indolepropionic acid-d₂

Name: 3-Indolepropionic acid-d 2
Brand: MedChemExpress
SKU: HY-W015229S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W015229S Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Indolepropionic acid-d₂ is the deuterium labeled 3-Indolepropionic acid. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

For research use only. We do not sell to patients.

3-Indolepropionic acid-d<sub>2</sub> Chemical Structure

3-Indolepropionic acid-d₂ Chemical Structure

CAS No. : 2469257-98-3

Size	Price	Stock	Quantity
1 mg	USD 256	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 640	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1020	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 3-Indolepropionic acid-d₂:

3-Indolepropionic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

3-Indolepropionic acid-d₂ is the deuterium labeled 3-Indolepropionic acid. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

191.22

Formula

C₁₁H₉D₂NO₂

CAS No.

2469257-98-3

Unlabeled CAS

830-96-6

Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])CC1=CNC2=CC=CC=C12)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (522.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1 mg/mL (5.23 mM; ultrasonic and warming and heat to 80°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2296 mL	26.1479 mL	52.2958 mL
5 mM	1.0459 mL	5.2296 mL	10.4592 mL
10 mM	0.5230 mL	2.6148 mL	5.2296 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (254 KB) HNMR (80 KB) RP-HPLC (114 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wikoff WR, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703. [Content Brief]

[3]. Reiter RJ, et al. Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin. Ann N Y Acad Sci. 1998 Nov 20;854:410-24. [Content Brief]

[4]. de Mello VDet al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO	1 mM	5.2296 mL	26.1479 mL	52.2958 mL	130.7395 mL
H₂O / H₂O / DMSO	5 mM	1.0459 mL	5.2296 mL	10.4592 mL	26.1479 mL
DMSO	10 mM	0.5230 mL	2.6148 mL	5.2296 mL	13.0739 mL
	15 mM	0.3486 mL	1.7432 mL	3.4864 mL	8.7160 mL
	20 mM	0.2615 mL	1.3074 mL	2.6148 mL	6.5370 mL
	25 mM	0.2092 mL	1.0459 mL	2.0918 mL	5.2296 mL
	30 mM	0.1743 mL	0.8716 mL	1.7432 mL	4.3580 mL
	40 mM	0.1307 mL	0.6537 mL	1.3074 mL	3.2685 mL
	50 mM	0.1046 mL	0.5230 mL	1.0459 mL	2.6148 mL
	60 mM	0.0872 mL	0.4358 mL	0.8716 mL	2.1790 mL
	80 mM	0.0654 mL	0.3268 mL	0.6537 mL	1.6342 mL
	100 mM	0.0523 mL	0.2615 mL	0.5230 mL	1.3074 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.