3-MeOARh-NTR 

3-MeOARh-NTR is an activatable imaging probe with high selectivity, and good stability. 3-MeOARh-NTR possesses high selectivity and high signal-to-noise ratio for nitroreductase (NTR) detection, and serves as an efficient molecular tool for endogenous NTR detection^[1].

3-MeOARh-NTR (10 μM, 30 min; cell incubated with 20% O₂ and 10% O₂ for 12 h) produces a strong fluorescence signal in living HeLa cells with decreasing oxygen contents^[1].
3-MeOARh-NTR (10 μM, 30 min) produces fluorescence imaging of kidney tissues from mice with λex = 488 nm and λem=510-590 nm. Thus, 3-MeOARh-NTR is a efficient probe to evaluate kidney hypoxia by NTR detection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

596.61

C₃₃H₃₀N₃O₈⁺

Solid

Pink to orange

CC/[N+](CC)=C1C=CC2=C(C3=C(OC2=C\1)C=C(C(OC)=C3)NC(OCC4=CC=C(C=C4)[N+]([O-])=O)=O)C5=C(C=CC=C5)C(O)=O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Guo H, et al. Designing a Brightness-Restored Rhodamine Derivative by the Ortho-Compensation Effect for Assessing Drug-Induced Acute Kidney Injury. Anal Chem. 2023 May 2;95(17):6863-6870.  [Content Brief]