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  2. Drug Intermediate
  3. 3-Methoxycatechol

3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models.

For research use only. We do not sell to patients.

3-Methoxycatechol Chemical Structure

3-Methoxycatechol Chemical Structure

CAS No. : 934-00-9

Size Price Stock Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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Description

3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models[1][2].

Cellular Effect
Cell Line Type Value Description References
MCF7 GI50
27.55 μM
Compound: 3c
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay
[PMID: 28041801]
TK-10 GI50
51.63 μM
Compound: 3c
Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay
[PMID: 28041801]
UACC-62 GI50
23.64 μM
Compound: 3c
Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay
[PMID: 28041801]
Molecular Weight

140.14

Formula

C7H8O3

CAS No.
Appearance

<42.8°C Solid,>42.8°C Liquid

Color

Colorless to off-white

SMILES

COC1=CC=CC(=C1O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1427.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1358 mL 35.6791 mL 71.3582 mL
5 mM 1.4272 mL 7.1358 mL 14.2716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.45%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.1358 mL 35.6791 mL 71.3582 mL 178.3956 mL
5 mM 1.4272 mL 7.1358 mL 14.2716 mL 35.6791 mL
10 mM 0.7136 mL 3.5679 mL 7.1358 mL 17.8396 mL
15 mM 0.4757 mL 2.3786 mL 4.7572 mL 11.8930 mL
20 mM 0.3568 mL 1.7840 mL 3.5679 mL 8.9198 mL
25 mM 0.2854 mL 1.4272 mL 2.8543 mL 7.1358 mL
30 mM 0.2379 mL 1.1893 mL 2.3786 mL 5.9465 mL
40 mM 0.1784 mL 0.8920 mL 1.7840 mL 4.4599 mL
50 mM 0.1427 mL 0.7136 mL 1.4272 mL 3.5679 mL
60 mM 0.1189 mL 0.5947 mL 1.1893 mL 2.9733 mL
80 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2299 mL
100 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7840 mL
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3-Methoxycatechol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3-Methoxycatechol
Cat. No.:
HY-W116576
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