3-Methoxycatechol

Cat. No.: HY-W116576 Purity: 99.45%: FAQs
Data Sheet SDS COA Handling Instructions

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3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models.

For research use only. We do not sell to patients.

3-Methoxycatechol Chemical Structure

CAS No. : 934-00-9

Size	Price	Stock
1 g	USD 25	Ask For Quote & Lead Time
5 g	USD 60	Ask For Quote & Lead Time
25 g	USD 180	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

3-Methoxycatechol is intermediate for the antivascular agents combretastatin A-1 (HY-121993) and combretastatin B-1. 3-Methoxycatechol promotes esophageal carcinogenesis in rats models^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI₅₀	27.55 μM Compound: 3c	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 28041801]
TK-10	GI₅₀	51.63 μM Compound: 3c	Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human TK10 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 28041801]
UACC-62	GI₅₀	23.64 μM Compound: 3c	Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay Cytotoxicity against human UACC62 cells assessed as cell growth inhibition after 48 hrs by SRB assay	[PMID: 28041801]

Molecular Weight

140.14

Formula

C₇H₈O₃

CAS No.

934-00-9

Appearance

<42.8°C Solid,>42.8°C Liquid

Color

Colorless to off-white

SMILES

COC1=CC=CC(=C1O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1427.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1357 mL	35.6786 mL	71.3572 mL
5 mM	1.4271 mL	7.1357 mL	14.2714 mL
10 mM	0.7136 mL	3.5679 mL	7.1357 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.45%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (257 KB) HNMR (117 KB) GC (180 KB)

Handling Instructions (2659 KB)

References

[1]. Tao Y, et al., Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone. J Bacteriol. 2004 Jul;186(14):4705-13. [Content Brief]

[2]. Hirose M, et al., Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer Res. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.1357 mL	35.6786 mL	71.3572 mL	178.3930 mL
	5 mM	1.4271 mL	7.1357 mL	14.2714 mL	35.6786 mL
	10 mM	0.7136 mL	3.5679 mL	7.1357 mL	17.8393 mL
	15 mM	0.4757 mL	2.3786 mL	4.7571 mL	11.8929 mL
	20 mM	0.3568 mL	1.7839 mL	3.5679 mL	8.9197 mL
	25 mM	0.2854 mL	1.4271 mL	2.8543 mL	7.1357 mL
	30 mM	0.2379 mL	1.1893 mL	2.3786 mL	5.9464 mL
	40 mM	0.1784 mL	0.8920 mL	1.7839 mL	4.4598 mL
	50 mM	0.1427 mL	0.7136 mL	1.4271 mL	3.5679 mL
	60 mM	0.1189 mL	0.5946 mL	1.1893 mL	2.9732 mL
	80 mM	0.0892 mL	0.4460 mL	0.8920 mL	2.2299 mL
	100 mM	0.0714 mL	0.3568 mL	0.7136 mL	1.7839 mL