1. Apoptosis
  2. Apoptosis
  3. 3-​O-​Acetyloleanolic acid

3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity.

For research use only. We do not sell to patients.

3-​O-​Acetyloleanolic acid Chemical Structure

3-​O-​Acetyloleanolic acid Chemical Structure

CAS No. : 4339-72-4

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Based on 1 publication(s) in Google Scholar

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Description

3-O-Acetyloleanolic acid (3AOA), an oleanolic acid derivative isolated from the seeds of Vigna sinensis K., induces in cancer and also exhibits anti-angiogenesis activity[1].

IC50 & Target

Apoptosis[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
5.8 μM
Compound: 1
Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay
Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay
[PMID: 31718182]
B16-F10 IC50
64.7 μM
Compound: V; OA-Ac
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against mouse B16F10 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
B16-F10 IC50
64.7 μM
Compound: 5
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT assay
[PMID: 24480359]
HepG2 IC50
> 100 μM
Compound: 10
Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 24974349]
HepG2 IC50
103.67 μM
Compound: V; OA-Ac
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
HT-29 IC50
148.48 μM
Compound: V; OA-Ac
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
[PMID: 27128174]
J774.A1 IC50
16.8 μM
Compound: 2
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
J774.A1 IC50
80.34 μM
Compound: 2
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
KB IC50
7.6 μM
Compound: 1
Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
MCF7 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
MDA-MB-231 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by SRB assay
[PMID: 31718182]
Neutrophil IC50
> 10 μg/mL
Compound: Table 3, R21C1
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins
[PMID: 28218000]
Neutrophil IC50
> 10 μg/mL
Compound: Table 3, R21C1
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate
[PMID: 28218000]
RAW264.7 IC50
13.8 μM
Compound: 2
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
[PMID: 25113933]
RAW264.7 IC50
79.23 μM
Compound: 2
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control
[PMID: 25113933]
Molecular Weight

498.74

Formula

C32H50O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)C4)CC3)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](OC(C)=O)CC5)C)([H])CC2)C)C

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0051 mL 10.0253 mL 20.0505 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0051 mL 10.0253 mL 20.0505 mL 50.1263 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
3-​O-​Acetyloleanolic acid
Cat. No.:
HY-N2618
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