3-sucCA (Synonyms: 3-Succinylated cholic acid)

Cat. No.: HY-158766 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid. 3-sucCA is a lumen-restricted metabolite and alleviates alleviates MAFL-MASH progression in mouse models by reshaping the gut microbiota, especially by promoting the growth of Akkermansia muciniphila. 3-sucCA levels are lower in patients with biopsy-proven MAFLD.

For research use only. We do not sell to patients.

3-sucCA Chemical Structure

CAS No. : 94159-47-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

508.64

Formula

C₂₈H₄₄O₈

CAS No.

94159-47-4

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(CCC(O)=O)=O)([H])C1)C)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (344.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9660 mL	9.8301 mL	19.6603 mL
5 mM	0.3932 mL	1.9660 mL	3.9321 mL
10 mM	0.1966 mL	0.9830 mL	1.9660 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (248 KB) HNMR (308 KB) RP-HPLC (213 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Nie Q, et al. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell. 2024 May 23;187(11):2717-2734.e33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9660 mL	9.8301 mL	19.6603 mL	49.1507 mL
	5 mM	0.3932 mL	1.9660 mL	3.9321 mL	9.8301 mL
	10 mM	0.1966 mL	0.9830 mL	1.9660 mL	4.9151 mL
	15 mM	0.1311 mL	0.6553 mL	1.3107 mL	3.2767 mL
	20 mM	0.0983 mL	0.4915 mL	0.9830 mL	2.4575 mL
	25 mM	0.0786 mL	0.3932 mL	0.7864 mL	1.9660 mL
	30 mM	0.0655 mL	0.3277 mL	0.6553 mL	1.6384 mL
	40 mM	0.0492 mL	0.2458 mL	0.4915 mL	1.2288 mL
	50 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9830 mL
	60 mM	0.0328 mL	0.1638 mL	0.3277 mL	0.8192 mL
	80 mM	0.0246 mL	0.1229 mL	0.2458 mL	0.6144 mL
	100 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.4915 mL

3-sucCA Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-sucCA94159-47-43-Succinylated cholic acidEndogenous MetaboliteMAFLDbile acidInhibitorinhibitorinhibit

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3-sucCA (Synonyms: 3-Succinylated cholic acid)

3-sucCA Related Antibodies

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