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3-sucCA  (Synonyms: 3-Succinylated cholic acid)

Cat. No.: HY-158766 Purity: 99.72%
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3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid. 3-sucCA is a lumen-restricted metabolite and alleviates alleviates MAFL-MASH progression in mouse models by reshaping the gut microbiota, especially by promoting the growth of Akkermansia muciniphila. 3-sucCA levels are lower in patients with biopsy-proven MAFLD.

For research use only. We do not sell to patients.

3-sucCA Chemical Structure

3-sucCA Chemical Structure

CAS No. : 94159-47-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 201 In-stock
Solution
10 mM * 1 mL in DMSO USD 201 In-stock
Solid
5 mg USD 180 In-stock
10 mg USD 280 In-stock
25 mg USD 470 In-stock
50 mg USD 750 In-stock
100 mg USD 1200 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

3-sucCA Related Antibodies

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Description

3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid. 3-sucCA is a lumen-restricted metabolite and alleviates alleviates MAFL-MASH progression in mouse models by reshaping the gut microbiota, especially by promoting the growth of Akkermansia muciniphila. 3-sucCA levels are lower in patients with biopsy-proven MAFLD[1].

Molecular Weight

508.64

Formula

C28H44O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(O)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(CCC(O)=O)=O)([H])C1)C)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (344.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9660 mL 9.8301 mL 19.6603 mL
5 mM 0.3932 mL 1.9660 mL 3.9321 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9660 mL 9.8301 mL 19.6603 mL 49.1507 mL
5 mM 0.3932 mL 1.9660 mL 3.9321 mL 9.8301 mL
10 mM 0.1966 mL 0.9830 mL 1.9660 mL 4.9151 mL
15 mM 0.1311 mL 0.6553 mL 1.3107 mL 3.2767 mL
20 mM 0.0983 mL 0.4915 mL 0.9830 mL 2.4575 mL
25 mM 0.0786 mL 0.3932 mL 0.7864 mL 1.9660 mL
30 mM 0.0655 mL 0.3277 mL 0.6553 mL 1.6384 mL
40 mM 0.0492 mL 0.2458 mL 0.4915 mL 1.2288 mL
50 mM 0.0393 mL 0.1966 mL 0.3932 mL 0.9830 mL
60 mM 0.0328 mL 0.1638 mL 0.3277 mL 0.8192 mL
80 mM 0.0246 mL 0.1229 mL 0.2458 mL 0.6144 mL
100 mM 0.0197 mL 0.0983 mL 0.1966 mL 0.4915 mL
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3-sucCA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-sucCA94159-47-43-Succinylated cholic acidOthersMAFLDbile acidInhibitorinhibitorinhibit

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