2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 

Cat. No.: HY-152819
Handling Instructions Technical Support

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Chemical Structure

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Chemical Structure

CAS No. : 847551-49-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
4.38 μM
Compound: 6
Cytotoxicity against human CCRF-CEM cells incubated for 3 days by XTT assay
Cytotoxicity against human CCRF-CEM cells incubated for 3 days by XTT assay
[PMID: 22877872]
DU-145 GI50
3.38 μM
Compound: 6
Cytostatic activity against human DU145 cells incubated for 3 days by SRB assay
Cytostatic activity against human DU145 cells incubated for 3 days by SRB assay
[PMID: 22877872]
HCT-116 GI50
6.65 μM
Compound: 6
Cytostatic activity against human HCT116 cells incubated for 3 days by SRB assay
Cytostatic activity against human HCT116 cells incubated for 3 days by SRB assay
[PMID: 22877872]
HeLa S3 IC50
7.5 μM
Compound: 6
Cytotoxicity against human HeLaS3 cells incubated for 3 days by XTT assay
Cytotoxicity against human HeLaS3 cells incubated for 3 days by XTT assay
[PMID: 22877872]
HL-60 IC50
> 10 μM
Compound: 6
Cytotoxicity against human HL60 cells incubated for 3 days by XTT assay
Cytotoxicity against human HL60 cells incubated for 3 days by XTT assay
[PMID: 22877872]
Huh-7 EC50
0.37 μM
Compound: 6
Antiviral activity against Hepatitis C virus subtype 1a replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
Antiviral activity against Hepatitis C virus subtype 1a replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
[PMID: 22877872]
Huh-7 EC50
0.38 μM
Compound: 6
Antiviral activity against Hepatitis C virus subtype 1b replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
Antiviral activity against Hepatitis C virus subtype 1b replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
[PMID: 22877872]
Huh-7 CC50
19.75 μM
Compound: 6
Toxicity against human HuH7 cells incubated for 3 days by CellTiter 96 AQueous One Solution cell proliferation assay
Toxicity against human HuH7 cells incubated for 3 days by CellTiter 96 AQueous One Solution cell proliferation assay
[PMID: 22877872]
NCI-H23 GI50
0.79 μM
Compound: 6
Cytostatic activity against human NCI-H23 cells incubated for 3 days by SRB assay
Cytostatic activity against human NCI-H23 cells incubated for 3 days by SRB assay
[PMID: 22877872]
Molecular Weight

406.18

Formula

C12H15IN4O4
CAS No.
SMILES

OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C=C(I)C3=C2N=CN=C3N)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine847551-49-9Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
Cat. No.:
HY-152819
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.