4″-C18 EGCG

Cat. No.: HY-168074: FAQs
Data Sheet Handling Instructions

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4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC₅₀ values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM.

For research use only. We do not sell to patients.

4″-C18 EGCG Chemical Structure

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Description	4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC₅₀ values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM^[1].
Molecular Weight	710.85
Formula	C₄₀H₅₄O₁₁
SMILES	OC(C(O)=C1)=C(O)C=C1[C@@H](O2)[C@H](OC(C3=CC(O)=C(OCCCCCCCCCCCCCCCCCC)C(O)=C3)=O)CC4=C2C=C(O)C=C4O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Kothari M, et al. Lipophilic derivatives of EGCG as potent α-amylase and α-glucosidase inhibitors ameliorating oxidative stress and inflammation[J]. Bioorganic Chemistry, 2024: 107786. [Content Brief]

4″-C18 EGCG Related Classifications

Metabolic Disease Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4″-C18 EGCGAmylasesGlucosidaseInhibitorOxidative stressAnti-diabeticPro-inflammatory cytokines3T3-L2 cell lineHEK293 cell linePeripheral blood mononuclear cellsinhibitorinhibit

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4″-C18 EGCG

4″-C18 EGCG Related Antibodies

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