4-Cumylphenol

Cat. No.: HY-W014282 Purity: 99.58%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Cumylphenol is a polycarbonate chain terminator. 4-Cumylphenol is widely used as a material for polycarbonate plastics, surfactants, fungicides and preservatives. 4-Cumylphenol also induces lipid accumulation in mouse adipocytes.

For research use only. We do not sell to patients.

4-Cumylphenol Chemical Structure

CAS No. : 599-64-4

Size	Price	Stock
1 g	USD 30	Ask For Quote & Lead Time
5 g	USD 80	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	13 μM Compound: 15	Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay Antagonist activity at human Gal4-fused ERbeta expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay	[PMID: 31980362]
HEK293	IC₅₀	24 μM Compound: 15	Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay Antagonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as inhibition of E2-induced transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay	[PMID: 31980362]
HEK293	EC₅₀	4.4 μM Compound: 15	Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay Agonist activity at human Gal4-fused ERalpha expressed in HEK293 cells assessed as transcriptional activation after 24 hrs by luciferase/beta-galactosidase reporter gene assay	[PMID: 31980362]
MCF7	EC₅₀	38 nM Compound: 15	Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay Estrogenic activity in human MCF7 cells assessed as cell proliferation after 7 days by WST-8 assay	[PMID: 23214428]

In Vitro

4-Cumylphenol (1, 5, 10, 20, 40 µM; 6 days) increase lipid accumulation in 3 T3-L1 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:	3 T3-L1 cells
Concentration:	1, 5, 10, 20, 40 µM
Incubation Time:	6 days
Result:	Increase lipid accumulation, which peaked at10 μM with a 204% increase.

Molecular Weight

212.29

Formula

C₁₅H₁₆O

CAS No.

599-64-4

Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=CC=C1)(C2=CC=C(O)C=C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (471.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7105 mL	23.5527 mL	47.1054 mL
5 mM	0.9421 mL	4.7105 mL	9.4211 mL
10 mM	0.4711 mL	2.3553 mL	4.7105 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.58%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) HNMR (121 KB) RP-HPLC (178 KB)

Handling Instructions (2659 KB)

References

[1]. Yue W, et al. Biodegradation of bisphenol-A polycarbonate plastic by Pseudoxanthomonas sp. strain NyZ600. J Hazard Mater. 2021 Aug 15;416:125775. [Content Brief]

[2]. Chiha M, et al. Sonolytic degradation of endocrine disrupting chemical 4-cumylphenol in water. Ultrason Sonochem. 2011 Sep;18(5):943-50. [Content Brief]

[3]. Ramskov Tetzlaff CN, Svingen T, et al. Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A. Environ Toxicol. 2020 May;35(5):543-552. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7105 mL	23.5527 mL	47.1054 mL	117.7634 mL
	5 mM	0.9421 mL	4.7105 mL	9.4211 mL	23.5527 mL
	10 mM	0.4711 mL	2.3553 mL	4.7105 mL	11.7763 mL
	15 mM	0.3140 mL	1.5702 mL	3.1404 mL	7.8509 mL
	20 mM	0.2355 mL	1.1776 mL	2.3553 mL	5.8882 mL
	25 mM	0.1884 mL	0.9421 mL	1.8842 mL	4.7105 mL
	30 mM	0.1570 mL	0.7851 mL	1.5702 mL	3.9254 mL
	40 mM	0.1178 mL	0.5888 mL	1.1776 mL	2.9441 mL
	50 mM	0.0942 mL	0.4711 mL	0.9421 mL	2.3553 mL
	60 mM	0.0785 mL	0.3925 mL	0.7851 mL	1.9627 mL
	80 mM	0.0589 mL	0.2944 mL	0.5888 mL	1.4720 mL
	100 mM	0.0471 mL	0.2355 mL	0.4711 mL	1.1776 mL

4-Cumylphenol Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Cumylphenol599-64-4Biochemical Assay Reagents3 T3-L1lipidplasticssurfactantsfungicidespreservativesInhibitorinhibitorinhibit

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