4-Formylcolchicine

Name: 4-Formylcolchicine
Brand: MedChemExpress
SKU: HY-147348
Rating: 4.5 (1 reviews)

Cat. No.: HY-147348 Purity: 99.32%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC₅₀ values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively.

For research use only. We do not sell to patients.

4-Formylcolchicine Chemical Structure

CAS No. : 2730-82-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 104	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 104	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 345	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC₅₀ values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.007 μM Compound: 7	Cytotoxicity against human A549 cells after 96 hrs using tetracolor one Cytotoxicity against human A549 cells after 96 hrs using tetracolor one	[PMID: 24900316]
HCT-116	IC₅₀	0.054 μM Compound: 7	Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one Cytotoxicity against human HCT116 cells after 96 hrs using tetracolor one	[PMID: 24900316]
HT-29	IC₅₀	0.128 μM Compound: 7	Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one	[PMID: 24900316]

In Vitro

4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC₅₀s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	A549, HT-29, HCT116 cells
Concentration:	0-5 µM
Incubation Time:	24 h
Result:	Inhibited cell growth with IC₅₀s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively.

Molecular Weight

427.45

Formula

C₂₃H₂₅NO₇

CAS No.

2730-82-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=C2C(C([C@H](CCC2=C(C(OC)=C1OC)C=O)NC(C)=O)=C3)=CC=C(OC)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL (374.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3395 mL	11.6973 mL	23.3945 mL
5 mM	0.4679 mL	2.3395 mL	4.6789 mL
10 mM	0.2339 mL	1.1697 mL	2.3395 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.32%

Select Batch:

Data Sheet (281 KB) SDS (251 KB)

COA (262 KB) HNMR (189 KB) RP-HPLC (263 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3395 mL	11.6973 mL	23.3945 mL	58.4864 mL
	5 mM	0.4679 mL	2.3395 mL	4.6789 mL	11.6973 mL
	10 mM	0.2339 mL	1.1697 mL	2.3395 mL	5.8486 mL
	15 mM	0.1560 mL	0.7798 mL	1.5596 mL	3.8991 mL
	20 mM	0.1170 mL	0.5849 mL	1.1697 mL	2.9243 mL
	25 mM	0.0936 mL	0.4679 mL	0.9358 mL	2.3395 mL
	30 mM	0.0780 mL	0.3899 mL	0.7798 mL	1.9495 mL
	40 mM	0.0585 mL	0.2924 mL	0.5849 mL	1.4622 mL
	50 mM	0.0468 mL	0.2339 mL	0.4679 mL	1.1697 mL
	60 mM	0.0390 mL	0.1950 mL	0.3899 mL	0.9748 mL
	80 mM	0.0292 mL	0.1462 mL	0.2924 mL	0.7311 mL
	100 mM	0.0234 mL	0.1170 mL	0.2339 mL	0.5849 mL