4-Hydroxyphenylacetic acid-d₆

Name: 4-Hydroxyphenylacetic acid-d 6
Brand: MedChemExpress
SKU: HY-N1902S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1902S Purity: 98.66%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

4-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 4-Hydroxyphenylacetic acid. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

For research use only. We do not sell to patients.

4-Hydroxyphenylacetic acid-d<sub>6</sub> Chemical Structure

4-Hydroxyphenylacetic acid-d₆ Chemical Structure

CAS No. : 100287-06-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxyphenylacetic acid-d₆:

4-Hydroxyphenylacetic acid In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

158.18

Formula

C₈H₂D₆O₃

CAS No.

100287-06-7

Unlabeled CAS

156-38-7

Appearance

Solid

Color

Off-white to pink

SMILES

OC(C([2H])([2H])C1=C([2H])C([2H])=C(C([2H])=C1[2H])O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (632.19 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.3219 mL	31.6096 mL	63.2191 mL
5 mM	1.2644 mL	6.3219 mL	12.6438 mL
10 mM	0.6322 mL	3.1610 mL	6.3219 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (251 KB) HNMR (481 KB) RP-HPLC (630 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.3219 mL	31.6096 mL	63.2191 mL	158.0478 mL
	5 mM	1.2644 mL	6.3219 mL	12.6438 mL	31.6096 mL
	10 mM	0.6322 mL	3.1610 mL	6.3219 mL	15.8048 mL
	15 mM	0.4215 mL	2.1073 mL	4.2146 mL	10.5365 mL
	20 mM	0.3161 mL	1.5805 mL	3.1610 mL	7.9024 mL
	25 mM	0.2529 mL	1.2644 mL	2.5288 mL	6.3219 mL
	30 mM	0.2107 mL	1.0537 mL	2.1073 mL	5.2683 mL
	40 mM	0.1580 mL	0.7902 mL	1.5805 mL	3.9512 mL
	50 mM	0.1264 mL	0.6322 mL	1.2644 mL	3.1610 mL
	60 mM	0.1054 mL	0.5268 mL	1.0537 mL	2.6341 mL
	80 mM	0.0790 mL	0.3951 mL	0.7902 mL	1.9756 mL
	100 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5805 mL