2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Estrogen Receptor/ERR Drug Metabolite
  4. 4'-Hydroxytamoxifen

4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells.

For research use only. We do not sell to patients.

4'-Hydroxytamoxifen Chemical Structure

4'-Hydroxytamoxifen Chemical Structure

CAS No. : 82413-23-8

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Other Forms of 4'-Hydroxytamoxifen:

4'-Hydroxytamoxifen Related Antibodies

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Description

4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].

Cellular Effect
Cell Line Type Value Description References
MCF7 IC50
0.0033 μM
Compound: 4-OHT
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human MCF7 cells after 5 days by coulter counter analysis
[PMID: 27529700]
MCF7 IC50
22 μM
Compound: 4-OHT
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant MCF7 cells after 5 days by coulter counter analysis
[PMID: 27529700]
MCF7 IC50
9.5 μM
Compound: 4-OHT
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 32283297]
T47D IC50
0.024 μM
Compound: 4-OHT
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
Antiproliferative activity against human T47D cells after 5 days by coulter counter analysis
[PMID: 27529700]
T47D IC50
0.54 μM
Compound: 4-OHT
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
Antiproliferative activity against human tamoxifen-resistant T47D cells over-expressing PKC-alpha after 5 days by coulter counter analysis
[PMID: 27529700]
Molecular Weight

387.51

Formula

C26H29NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (51.61 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5806 mL 12.9029 mL 25.8058 mL
5 mM 0.5161 mL 2.5806 mL 5.1612 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
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C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.2%

SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.5806 mL 12.9029 mL 25.8058 mL 64.5145 mL
5 mM 0.5161 mL 2.5806 mL 5.1612 mL 12.9029 mL
10 mM 0.2581 mL 1.2903 mL 2.5806 mL 6.4514 mL
15 mM 0.1720 mL 0.8602 mL 1.7204 mL 4.3010 mL
20 mM 0.1290 mL 0.6451 mL 1.2903 mL 3.2257 mL
25 mM 0.1032 mL 0.5161 mL 1.0322 mL 2.5806 mL
30 mM 0.0860 mL 0.4301 mL 0.8602 mL 2.1505 mL
40 mM 0.0645 mL 0.3226 mL 0.6451 mL 1.6129 mL
50 mM 0.0516 mL 0.2581 mL 0.5161 mL 1.2903 mL
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4'-Hydroxytamoxifen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4'-Hydroxytamoxifen82413-23-8Estrogen Receptor/ERRDrug MetaboliteInhibitorinhibitorinhibit

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